This paper reports on the feasibility, acceptability, and effectiveness of an innovative implementation strategy named “systems consultation” aimed at improving adherence to clinical guidelines for opioid pres...
Authors: Andrew Quanbeck, Randall T. Brown, Aleksandra E. Zgierska, Nora Jacobson, James M. Robinson, Roberta A. Johnson, Brienna M. Deyo, Lynn Madden, Wen-Jan Tuan and Esra Alagoz
The GRADE-CERQual (‘Confidence in the Evidence from Reviews of Qualitative research’) approach provides guidance for assessing how much confidence to place in findings from systematic reviews of qualitative re...
Authors: Simon Lewin, Andrew Booth, Claire Glenton, Heather Munthe-Kaas, Arash Rashidian, Megan Wainwright, Meghan A. Bohren, Özge Tunçalp, Christopher J. Colvin, Ruth Garside, Benedicte Carlsen, Etienne V. Langlois and Jane Noyes
The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group. The a...
Authors: Andrew Booth, Simon Lewin, Claire Glenton, Heather Munthe-Kaas, Ingrid Toews, Jane Noyes, Arash Rashidian, Rigmor C. Berg, Brenda Nyakang’o and Joerg J. Meerpohl
An estimated 2.6 million newborns died in 2016; over 98.5% of deaths occurred in low- and middle-income countries (LMICs). Neonates born preterm and small for gestational age are particularly at risk given the...
Authors: Nabila Zaka, Emma C. Alexander, Logan Manikam, Irena C. F. Norman, Melika Akhbari, Sarah Moxon, Pavani Kalluri Ram, Georgina Murphy, Mike English, Susan Niermeyer and Luwei Pearson
The GRADE-CERQual (Grading of Recommendations Assessment, Development and Evaluation-Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE working group. The app...
Authors: Christopher J. Colvin, Ruth Garside, Megan Wainwright, Heather Munthe-Kaas, Claire Glenton, Meghan A. Bohren, Benedicte Carlsen, Özge Tunçalp, Jane Noyes, Andrew Booth, Arash Rashidian, Signe Flottorp and Simon Lewin
The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group. The a...
Authors: Simon Lewin, Meghan Bohren, Arash Rashidian, Heather Munthe-Kaas, Claire Glenton, Christopher J. Colvin, Ruth Garside, Jane Noyes, Andrew Booth, Özge Tunçalp, Megan Wainwright, Signe Flottorp, Joseph D. Tucker and Benedicte Carlsen
The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group. The a...
Authors: Jane Noyes, Andrew Booth, Simon Lewin, Benedicte Carlsen, Claire Glenton, Christopher J. Colvin, Ruth Garside, Meghan A. Bohren, Arash Rashidian, Megan Wainwright, Özge Tunςalp, Jacqueline Chandler, Signe Flottorp, Tomas Pantoja, Joseph D. Tucker and Heather Munthe-Kaas
The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) working group. The a...
Authors: Claire Glenton, Benedicte Carlsen, Simon Lewin, Heather Munthe-Kaas, Christopher J. Colvin, Özge Tunçalp, Meghan A. Bohren, Jane Noyes, Andrew Booth, Ruth Garside, Arash Rashidian, Signe Flottorp and Megan Wainwright
The GRADE-CERQual (Confidence in Evidence from Reviews of Qualitative research) approach has been developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) Working Group. The a...
Authors: Heather Munthe-Kaas, Meghan A. Bohren, Claire Glenton, Simon Lewin, Jane Noyes, Özge Tunçalp, Andrew Booth, Ruth Garside, Christopher J. Colvin, Megan Wainwright, Arash Rashidian, Signe Flottorp and Benedicte Carlsen
Workplace-based clinical supervision as an implementation strategy to support evidence-based treatment (EBT) in public mental health has received limited research attention. A commonly provided infrastructure ...
Authors: Shannon Dorsey, Suzanne E. U. Kerns, Leah Lucid, Michael D. Pullmann, Julie P. Harrison, Lucy Berliner, Kelly Thompson and Esther Deblinger
As the field of D&I (dissemination and implementation) science grows to meet the need for more effective and timely applications of research findings in routine practice, the demand for formalized training pro...
Authors: Margaret Padek, Nageen Mir, Rebekah R. Jacob, David A. Chambers, Maureen Dobbins, Karen M. Emmons, Jon Kerner, Shiriki Kumanyika, Christine Pfund, Enola K. Proctor, Kurt C. Stange and Ross C. Brownson
Despite our progress in understanding the organizational context for implementation and specifically the role of leadership in implementation, its role in sustainment has received little attention. This paper ...
Authors: Mark G. Ehrhart, Elisa M. Torres, Amy E. Green, Elise M. Trott, Cathleen E. Willging, Joanna C. Moullin and Gregory A. Aarons
Antimicrobial stewardship to combat the spread of antibiotic-resistant bacteria has become a national priority. This project focuses on reducing inappropriate use of antimicrobials for asymptomatic bacteriuria...
Authors: Barbara W. Trautner, Pooja Prasad, Larissa Grigoryan, Sylvia J. Hysong, Jennifer R. Kramer, Suja Rajan, Nancy J. Petersen, Tracey Rosen, Dimitri M. Drekonja, Christopher Graber, Payal Patel, Paola Lichtenberger, Timothy P. Gauthier, Steve Wiseman, Makoto Jones, Anne Sales…
While sepsis-related mortality decreased substantially in other developed countries, mortality of severe sepsis remained as high as 44% in Germany. A recent German cluster randomized trial was not able to impr...
Authors: Daniel Schwarzkopf, Hendrik Rüddel, Matthias Gründling, Christian Putensen and Konrad Reinhart
Pediatric obesity is a multi-faceted public health concern that can lead to cardiovascular diseases, cancers, and early mortality. Small changes in diet, physical activity, or BMI can significantly reduce the ...
Authors: Justin D. Smith, Cady Berkel, Neil Jordan, David C. Atkins, Shrikanth S. Narayanan, Carlos Gallo, Kevin J. Grimm, Thomas J. Dishion, Anne M. Mauricio, Jenna Rudo-Stern, Mariah K. Meachum, Emily Winslow and Meg M. Bruening
Evidence supports magnesium sulphate (MgSO4) for women at risk of imminent birth at < 32–34 weeks to reduce the likelihood of cerebral palsy in the child. MAGnesium sulphate for fetal neuroprotection to preven...
Authors: Dane A. De Silva, Anne R. Synnes, Peter von Dadelszen, Tang Lee, Jeffrey N. Bone and Laura A. Magee
In Belgium, the debate about the effect of the national academic detailing service (ADS) on prescribing quality in general practice is ongoing. In order to evaluate both the implementation strategies of the AD...
Authors: Robin Bruyndonckx, Veronique Verhoeven, Sibyl Anthierens, Koen Cornelis, Katelijne Ackaert, Birgit Gielen and Samuel Coenen
Drug expenditures are responsible for an increasing proportion of health costs, accounting for $1.1 trillion in annual expenditure worldwide. As hundreds of billions of dollars are being spent each year on ove...
Authors: Robyn Tamblyn, Nancy Winslade, Christina J. Qian, Teresa Moraga and Allen Huang
A substantial literature has established the role of the inner organizational setting on the implementation of evidence-based practices in community contexts, but very little of this research has been extended...
Authors: Aaron R. Lyon, Clayton R. Cook, Eric C. Brown, Jill Locke, Chayna Davis, Mark Ehrhart and Gregory A. Aarons
This study examines how system-wide (i.e., region, district, and school) mechanisms such as leadership support, training requirements, structure, collaboration, and education affect the use of evidence-based p...
Authors: Aubyn C. Stahmer, Jessica Suhrheinrich, Patricia L. Schetter and Elizabeth McGee Hassrick
Sweden has a policy of supporting older people to live a normal life at home for as long as possible. Therefore, it is often the oldest, most frail people who move into nursing homes. Nursing home staff are ex...
Authors: Per Nilsen, Birgitta Wallerstedt, Lina Behm and Gerd Ahlström
Every safety-critical industry devotes considerable time and resource to investigating and analysing accidents, incidents and near misses. The systematic analysis of incidents has greatly expanded our understa...
Authors: Charles Vincent, Jane Carthey, Carl Macrae and Rene Amalberti
Web-based interventions to support people to manage long-term health conditions are available and effective but rarely used in clinical services. The aim of this study is to identify critical factors impacting...
Authors: Fiona Lobban, Victoria Appleton, Duncan Appelbe, Johanna Barraclough, Julie Bowland, Naomi R Fisher, Sheena Foster, Sonia Johnson, Elizabeth Lewis, Céu Mateus, Barbara Mezes, Elizabeth Murray, Puffin O’Hanlon, Vanessa Pinfold, Jo Rycroft-Malone, Ron Siddle…
Few measures of research use in health policymaking are available, and the reliability of such measures has yet to be evaluated. A new measure called the Staff Assessment of Engagement with Evidence (SAGE) inc...
Authors: Steve R. Makkar, Anna Williamson, Catherine D’Este and Sally Redman
Better use of research evidence (one form of “knowledge”) in health systems requires partnerships between researchers and those who contend with the real-world needs and constraints of health systems. Communit...
Authors: Janet Jull, Audrey Giles and Ian D. Graham
Informed by our prior work indicating that therapists do not feel recognized or rewarded for implementation of evidence-based practices, we tested the feasibility and acceptability of two incentive-based imple...
Authors: Rinad S. Beidas, Emily M. Becker-Haimes, Danielle R. Adams, Laura Skriner, Rebecca E. Stewart, Courtney Benjamin Wolk, Alison M. Buttenheim, Nathaniel J. Williams, Patricia Inacker, Elizabeth Richey and Steven C. Marcus
Laboratory testing is an important clinical act with a valuable role in screening, diagnosis, management and monitoring of diseases or therapies. However, inappropriate laboratory test ordering is frequent, bu...
Authors: Nicolas Delvaux, An De Sutter, Stijn Van de Velde, Dirk Ramaekers, Steffen Fieuws and Bert Aertgeerts
The effectiveness of many interventions to promote health and prevent disease has been well established. The imperative has therefore shifted from amassing evidence about efficacy to scale-up to maximise popul...
Authors: Kathleen P. Conte, Sisse Groen, Victoria Loblay, Amanda Green, Andrew Milat, Lina Persson, Christine Innes-Hughes, Jo Mitchell, Sarah Thackway, Mandy Williams and Penelope Hawe
A range of evidence informs decision-making on innovation in health care, including formal research findings, local data and professional opinion. However, cultural and organisational factors often prevent the...
Authors: Simon Turner, Danielle D’Lima, Emma Hudson, Stephen Morris, Jessica Sheringham, Nick Swart and Naomi J. Fulop
Studying de-implementation—defined herein as reducing or stopping the use of a health service or practice provided to patients by healthcare practitioners and systems—has gained traction in recent years. De-im...
Authors: Wynne E. Norton, Amy E. Kennedy and David A. Chambers
Although the importance of evaluating implementation fidelity is acknowledged, little is known about heterogeneity in fidelity over time. This study aims to generate insight into the heterogeneity in implement...
Authors: Femke Hoekstra, Marjolein A. G. van Offenbeek, Rienk Dekker, Florentina J. Hettinga, Trynke Hoekstra, Lucas H. V. van der Woude and Cees P. van der Schans
Care bundles are a set of three to five evidence-informed practices performed collectively and reliably to improve the quality of care. Care bundles are used widely across healthcare settings with the aim of p...
Authors: Jacqueline F. Lavallée, Trish A. Gray, Jo Dumville, Wanda Russell and Nicky Cullum
In 2011, Manitoba implemented a province-wide program of physician detailing and free sampling for generic atorvastatin to increase use of this generic statin. We examined the impact of this unique combined pr...
Authors: Heather C. Worthington, Lucy Cheng, Sumit R. Majumdar, Steven G. Morgan, Colette B. Raymond, Stephen B. Soumerai and Michael R. Law
One of the key strategies to successful implementation of effective health-related interventions is targeting improvements in stakeholder engagement. The discrete choice experiment (DCE) is a stated preference...
Authors: Ramzi G. Salloum, Elizabeth A. Shenkman, Jordan J. Louviere and David A. Chambers
While an extensive array of existing evidence-based practices (EBPs) have the potential to improve patient outcomes, little is known about how to implement EBPs on a larger scale. Therefore, we sought to ident...
Authors: Ali Ben Charif, Hervé Tchala Vignon Zomahoun, Annie LeBlanc, Léa Langlois, Luke Wolfenden, Sze Lin Yoong, Christopher M. Williams, Roxanne Lépine and France Légaré
The recent growth in organized efforts to advance dissemination and implementation (D & I) science suggests a rapidly expanding community focused on the adoption and sustainment of evidence-based practices (EB...
Authors: Doyanne Darnell, Caitlin N. Dorsey, Abigail Melvin, Jonathan Chi, Aaron R. Lyon and Cara C. Lewis
Implementation strategies are imperative for the successful adoption and sustainability of complex evidence-based public health practices. Creating a learning collaborative is one strategy that was part of a r...
Authors: Carla L. DeSisto, Cameron Estrich, Charlan D. Kroelinger, David A. Goodman, Ellen Pliska, Christine N. Mackie, Lisa F. Waddell and Kristin M. Rankin
Overdoses due to non-medical use of prescription opioids and other opiates have become the leading cause of accidental deaths in the USA. Buprenorphine and extended-release naltrexone are key evidence-based ph...
Authors: Todd Molfenter, Hannah K. Knudsen, Randy Brown, Nora Jacobson, Julie Horst, Mark Van Etten, Jee-Seon Kim, Eric Haram, Elizabeth Collier, Sanford Starr, Alexander Toy and Lynn Madden
Guideline implementation tools (GI tools) can improve clinician behavior and patient outcomes. Analyses of guidelines published before 2010 found that many did not offer GI tools. Since 2010 standards, framewo...
Authors: Laurel Liang, Jhoni Abi Safi and Anna R. Gagliardi
Individuals with severe mental illness (e.g., schizophrenia, bipolar disorder) die 10–25 years earlier than the general population, primarily from premature cardiovascular disease (CVD). Contributing factors a...
Authors: Christina Mangurian, Grace C. Niu, Dean Schillinger, John W. Newcomer, James Dilley and Margaret A. Handley
Leadership style and specific organizational climates have emerged as critical mechanisms to implement targeted practices in organizations. Drawing from relevant theories, we propose that climate for implement...
Authors: Erick G. Guerrero, Karissa Fenwick and Yinfei Kong
The aim of this mixed-methods, systematic literature review was to develop an understanding of the factors affecting the implementation of tobacco and substance use intervention programmes in the secondary sch...
Authors: Gillian Waller, Tracy Finch, Emma L. Giles and Dorothy Newbury-Birch
It is widely acknowledged that health policy and management decisions rarely reflect research evidence. Therefore, it is important to determine how to improve evidence-informed decision-making. The primary aim...
Authors: Mitchell N. Sarkies, Kelly-Ann Bowles, Elizabeth H. Skinner, Romi Haas, Haylee Lane and Terry P. Haines
Implementing research findings into healthcare practice and policy is a complex process occurring in diverse contexts; it invariably depends on changing human behaviour in many parts of an intricate implementa...
A large and compelling clinical evidence base has shown that integrated TB and HIV services leads to reduction in human immunodeficiency virus (HIV)- and tuberculosis (TB)-associated mortality and morbidity. D...
Authors: Kogieleum Naidoo, Santhanalakshmi Gengiah, Nonhlanhla Yende-Zuma, Nesri Padayatchi, Pierre Barker, Andrew Nunn, Priashni Subrayen and Salim S. Abdool Karim
Organizational readiness to change healthcare practice is a major determinant of successful implementation of evidence-based interventions. However, we lack of comprehensive, valid, and reliable instruments to...
Authors: Gonzalo Grandes, Paola Bully, Catalina Martinez and Marie-Pierre Gagnon
The Enhancing Mental and Physical health of Women through Engagement and Retention or EMPOWER program represents a partnership with the US Department of Veterans Health Administration (VA) Health Service Resea...
Authors: Alison B. Hamilton, Melissa M. Farmer, Tannaz Moin, Erin P. Finley, Ariel J. Lang, Sabine M. Oishi, Alexis K. Huynh, Jessica Zuchowski, Sally G. Haskell and Bevanne Bean-Mayberry
To improve management of severely ill hospitalized patients in low-income settings, the World Health Organization (WHO) established a triage tool called “Quick Check” to provide clinicians with a rapid, standa...
Authors: Matthew J. Cummings, Elijah Goldberg, Savio Mwaka, Olive Kabajaasi, Eric Vittinghoff, Adithya Cattamanchi, Achilles Katamba, Nathan Kenya-Mugisha, Shevin T. Jacob and J. Lucian Davis
Strategies are central to the National Institutes of Health’s definition of implementation research as “the study of strategies to integrate evidence-based interventions into specific settings.” Multiple schol...
Authors: Jennifer Leeman, Sarah A. Birken, Byron J. Powell, Catherine Rohweder and Christopher M. Shea
Theories provide a synthesizing architecture for implementation science. The underuse, superficial use, and misuse of theories pose a substantial scientific challenge for implementation science and may relate ...
Authors: Sarah A. Birken, Byron J. Powell, Christopher M. Shea, Emily R. Haines, M. Alexis Kirk, Jennifer Leeman, Catherine Rohweder, Laura Damschroder and Justin Presseau
