A geographical cluster randomised stepped wedge study of continuing medical education and cancer diagnosis in general practice
Implementation Science volume 9, Article number: 159 (2014)
Denmark has inferior cancer survival rates compared with many European countries. The main reason for this is suggested to be late diagnosis at advanced cancer stages. Cancer diagnostic work-up begins in general practice in 85% of all cancer cases. Thus, general practitioners (GPs) play a key role in the diagnostic process. The latest Danish Cancer Plan included continuing medical education (CME) on early cancer diagnosis in general practice to improve early diagnosis. This dual aims of this protocol are, first, to describe the conceptualisation, operationalisation and implementation of the CME and, second, to describe the study design and outcomes chosen to evaluate the effects of the CME.
The intervention is a CME in early cancer diagnosis targeting individual GPs. It was developed by a step-wise approach. Barriers for early cancer diagnosis at GP level were identified systematically and analysed using the behaviour system involving capability, opportunity and motivation described by Michie et al. The study will be designed as a geographical cluster randomised stepped wedge study. The study population counts 836 GPs from 417 general practices in the Central Denmark Region, geographically divided into eight clusters. GPs from each cluster will be invited to a CME meeting at a certain date three weeks apart. The primary outcomes will be primary care interval and GP referral rate on cancer suspicion. Data will be obtained from national registries, GP-completed forms on patients referred to cancer fast-track pathways and GP-completed online questionnaires before and after the intervention.
To our knowledge, this will be the first study to measure the effect of a theory-based CME in early cancer diagnosis at three levels: GP knowledge and attitude, GP activity and patient outcomes. The achieved knowledge will contribute to the understanding of whether and how general practice’s ability to perform cancer diagnosis may be improved.
Registered as NCT02069470 on ClinicalTrials.gov.
Denmark lags behind many European countries in cancer survival. It has been suggested that late diagnosis and more advanced cancer stage at treatment lie at the root of this problem -. In order to minimise the time from referral to diagnosis, some countries have implemented fast-track pathways for cancer, e.g. the 2-week wait in the United Kingdom and the cancer pathways in Denmark ,. Such organisational initiatives are largely dependent on the prevailing referral patterns in general practice. Selecting patients for referral for suspected cancer is a complex procedure which is influenced by 1) the general practitioner’s (GP’s) personal characteristics such as knowledge, skills, clinical judgement, risk-taking disposition and attitude; 2) organisational factors such as access to tests and investigations; and 3) patient-related factors such as expectations, symptom presentation and communication-style preferences. It is by no means a straightforward task to set the bar for referral . Over-investigation has clinical and financial consequences, whereas under-investigation may delay diagnosis and have medico-legal implications.
The key role of general practice in earlier cancer diagnosis is indisputable; 85% of Danish cancer patients presented symptoms to general practitioners on their route to diagnosis . Previous studies have found that cancer patients had an increased number of visits to general practitioners 6 months prior to diagnosis  and that 25% of all cancer patients had a primary care interval of more than 20 days until referral according to the GPs ,. Thus, there seems to be a potential for earlier referral and possibly also for earlier diagnosis -. However, as the average Danish GP sees only eight to ten new cancer patients per year, cancer is a relatively rare disease in primary care. Half of the diagnosed cancer patients are known to present with what the GPs report as alarm symptoms, while the other half tend to present with non-specific or vague symptoms ,. When patients present cancer-related symptoms to general practitioners, their probability of having cancer is low because even alarm symptoms of cancer have low positive predictive values (PPVs; below 5%) -. Yet, the proportion of cancer patients among patients referred to cancer fast-track pathways is high (PPVs of 10%–30%) ,, which implies that the GPs may somehow introduce a higher threshold for referral.
To improve cancer diagnostics in Denmark, the latest Danish Cancer Plan included continuing medical education (CME) targeting GPs as a key strategy to optimise cancer symptom recognition among GPs and to facilitate referral to fast-track pathways. The CME initiative provided an important opportunity to measure if and how targeted CME may influence the participating GPs’ knowledge, attitude and activity in the context of referral for cancer suspicion.
The primary aim of this article is to describe the conceptualisation, operationalisation and implementation of CME to enhance cancer diagnostics in primary care. A second aim is to describe the study design and outcomes chosen to evaluate the effects of the CME.
The CME intervention
The study was performed in one of the five Danish Regions (Central Denmark Region) which has 1.27 million inhabitants and 417 GP clinics with 836 GPs. In Denmark, GPs own their private clinics and are on a contract with the Danish Regions on a central, negotiated scheme . Part of this scheme includes remuneration for participation in CME. As a first line in the Danish healthcare system, the GPs provide free access to medical advice and act as gatekeepers to hospital and private specialists. Each citizen (99%) is listed with a specific general practice clinic.
The regional CME on early cancer diagnosis was initiated by a team comprising researchers, a regional academic coordinator, hospital-GP liaison advisors, a CME supervisor and three leading hospital consultants. A working group was established to operationalise the CME. This group counted four academic GPs of whom two were hospital-GP liaison advisors, one CME supervisor and one researcher (BST). A research group (the authors) identified the barriers as described below. The Danish government funded the CME.
Identification of barriers at GP level for early cancer diagnosis
The key aim of the CME was to optimise cancer-related referral from general practice clinic to hospital in an attempt to identify underlying cancers at an earlier and more amenable stage. The target for the intervention was the individual GP, and the CME was developed in a stepwise manner as described by Grol et al. . Initially, the research group identified barriers at the GP level for early referral using a number of methods: input from research literature, brainstorm among the four GPs in the working group, individual GP interviews made by the first author (BST), a focus group interview with six GPs , experiences from audit of lung cancer diagnosis in general practice in the UK , and Danish GPs’ responses to the Module 3 International Cancer Benchmarking Partnership (ICBP) questionnaire . The barriers identified through this process were shared with the members of the working group, and they were included in the CME if considered both important and possible to change (Figure 1).
One barrier was "Insufficient GP knowledge about the positive predictive values (PPV) of cancer symptoms". This barrier signifies that GPs have not acquired full knowledge of the PPVs based on primary care populations -,. It was hypothesised that this could prevent GPs from knowing what would be the PPV upon referral of patients to the fast-track cancer pathway (below 10%). Another barrier was "Lack of recognition of the `low-risk-but-not-no-risk' symptoms". This barrier reveals the absence of awareness of non-specific, vague symptoms ,. "Lack of knowledge on benefits of early diagnosis" suggests an insufficient understanding of the fact that 2–4 weeks' delay in diagnosis may cause stage progression for some cancers  and that waiting time in general can have an impact on prognosis ,. Another important issue, "false reassurance from a normal test and other pitfalls", covers the fact that GPs felt reassurance when an ordered test turned out normal or was used on mistaken indications. This reassurance could arise because of the false negative nature of the results (e.g. chest x-ray missing 15-20% of lung cancers ) or because a negative test result was used to exclude a cancer diagnosis (e.g. normal blood counts). Awareness of typical pitfalls  in early cancer diagnosis was thus considered important to the GP’s choice and interpretation of a test.
"High risk-taking" indicates the existence of a high GP referral threshold . The threshold is considered to be too high since the observed proportion of cancer patients in Danish fast-track pathways (typically 10-30%) , is higher than the PPVs of alarm symptoms. "Low use of fast-track pathway referral for cancer suspicion" indicates that in some situations GPs refer patient to an ordinary hospital investigation rather than to the more optimal cancer fast-track pathway. This could be explained by an incomplete implementation or a concern for overuse of the fast-track referral option. "Inadequate experience with online cancer guidelines" indicates a need for more experience in the use of the regional website for referral. It was hypothesised that such a website would heighten the GPs’ knowledge about referral criteria and receiving departments and that the presence of this website would allow the GPs an opportunity to better inform the patient about the investigation and overall reduce time spent. "Difficulties in communicating cancer risk" concealed an uncertainty in how to communicate risk to a patient. This item was evaluated as important since, opposite ordinary referral, referral to a fast-track pathway required that the GP informed the patient about their suspicion of cancer. Thus, some GPs did not refer patients to cancer fast-track investigation as they did not want to worry the patient.
Addressing the identified barriers and developing the CME elements
According to the theoretical frame described by Michie et al. , any changes in the GP’s clinical behaviour (B) will be governed by their psychological and physical capability (C), social opportunity (O) and motivation (M) to change. Using this COM-B-model, the identified barriers were analysed, and the elements of the CME were subsequently developed (Table 1).
The psychological capability is the GP’s ability to engage in the necessary thought processes related to comprehension and reasoning. The cognitive part of the CME would increase the GP’s knowledge about the PPVs of cancer symptoms and increase his or her awareness of the identified pitfalls in cancer diagnosis. This was believed to lead the GP to perform a more correct cancer risk assessment and thereby optimise referral procedures. The CME would point out that referral-delay could worsen the prognosis to dispel the myth that cancer develops over several years and that another month therefore would not change the prognosis ,.
The physical capability covers the skills necessary to perform concrete manoeuvres. The CME reintroduced how to access the regional website and shortly described the contents and search tool. Furthermore, the communication skills about cancer were addressed through case-based discussion on how and when to inform a patient about cancer risk.
The GPs’ physical opportunity to refer patients suspected of having cancer exists through the already established fast-track pathways and existing guidelines. The CME included no intervention in this area. The social opportunity was indirectly addressed by including a local opinion leader and a local hospital consultant in the team of lecturers to emphasise that a change of attitude towards lowering the referral threshold is widely recommended.
Motivation includes the reflective processes involving evaluation. Risk taking was addressed through case-based discussion and by raising questions about what it implies to be a competent GP. Motivation also comprised automatic processes involving emotions and impulses arising from associative learning. To address these processes, the CME included an educational film developed to illustrate a GP’s handling of a patient with a complex medical history. By identifying with the GP actor and by subsequently discussing his struggle and lack of readiness to do the definitive investigation, it was intended that the GPs would store this experience in their mind for later pattern recognition.
Form of CME
The CME took place as a 3-hour session. According to the available evidence, the teaching approach was multifaceted, partly didactic, but mostly interactive ,. The key points were first explained and illustrated by an oral presentation, next they were discussed in a reflective debate based on two clinical patient scenarios and one educational film to create a scenario similar to that encountered in clinical practice and decision-making. Hands-on models of tumours were placed in the lecture room. PPV diagrams on lung, colorectal, ovarian and prostate cancer - were printed in hard copy as a clinical tool. Furthermore, leaflets for specific fast-track pathway to support communication about risk of cancer were offered in a plastic retainer, also to bring home to the clinic. The CME schedule is shown in Table 2.
The CME sessions were conducted by a team of six persons with different healthcare backgrounds. They consisted of an academic primary care researcher to increase the new evidence-based knowledge; two hospital-GP liaison advisors to reduce the gap between research knowledge and everyday life in practice; a local CME supervisor to establish a safe atmosphere and to facilitate acceptance of the knowledge by being considered a local opinion leader; a local hospital consultant to guarantee that the proposed changes could be anchored locally and to ensure a debate of any local issues that could act as barriers to the implementation. A regional academic coordinator introduced the program and ensured that time was kept.
The CME was intended to reach as many GPs as possible in the Central Denmark Region. Geographical accessibility was therefore important, and the CME sessions were accordingly arranged as eight local meetings. The meeting rooms had high-quality audio-visual equipment and were laid out with round tables for 6–8 people. Participants were offered catering during the meeting, and a friendly, relaxed atmosphere was established.
A full-scale CME session was conducted with the Regional Cancer Steering group as audience. Feedback from the session was used to further adapt the CME.
The effect of the CME intervention will be evaluated in a geographical cluster randomised stepped wedge design . All GPs in the Central Denmark Region were allocated to one of eight clusters based on their clinics’ geographical location. CME was offered as a 3-hour meeting to each cluster with 3 weeks’ interval in between clusters. Clusters with delayed intervention will serve as controls for clusters that have already received interventions (Figure 2).
The Regional Cancer Care Unit generated the random allocation sequence which was based on the pragmatic principle that dates for CME should be applicable for that geographical area (taking into account other arrangements in the area, the availability of venue, etc.). The same independent administrative unit enrolled and assigned clusters to the CME. The researchers were not involved in the randomisation. The GPs were not aware of the interventional design. The main researcher was present at the meeting, but only to register participants and to observe that the CME was delivered as planned to evaluate uniformity. She could not interfere with the participants or the CME conduct.
Study population and recruitment of GPs to the CME
All GPs from the Central Denmark Region were invited to the CME. The CME was announced in each cluster by mail invitations 2 months before and again 1 month before the CME. Additionally, the description of the meeting was available on the regional GP website. Each GP willing to participate in the CME was registered at sign-up and again upon arrival at the CME.
Inclusion and exclusion criteria for patients
Included are all patients referred from general practice to the fast-track pathway for cancer except patients suspected for non-melanoma skin cancer. Excluded are patients already diagnosed with cancer within five years prior to the date of referral.
The primary outcomes
Primary care interval is defined as the time from the first presentation of a cancer-relevant symptom in primary care until the date of referral to secondary care for investigation . It was hypothesised that the CME would lower the primary care interval by increasing the GP’s readiness to refer.
GP referral rate is defined as the number of patients referred by a specific GP to a cancer fast-track pathway per 1000 patients listed with the GP. The CME was expected to increase the referral rate.
The secondary outcomes
GP knowledge is defined as knowledge on i) Cancer as a condition with a low prevalence, ii) PPVs for cancer of selected symptoms, iii) Typical pitfalls and iii) Initial cancer presentation. This is measured by requesting the GP to indicate a probability percentage (0-100%) on questions such as; what is the likelihood of a 50-year-old patient having cancer at the time you choose to refer to a cancer fast-track pathway? What is the likelihood of a patient, smoker, aged 40 and above, having lung cancer the second time the patient presents with haemoptysis in your practice? What is the risk for a lung cancer not being detected on a chest x-ray at the time of diagnosis? What is the proportion of patients with colorectal cancer who initial presented an alarm symptom?
GP attitude towards early cancer diagnosis, assessed as a score on a 1–5 Likert scale. It is defined as attitude to i) Use of fast-track referral, i.e. whether the referral option is considered complicated and/or time-consuming. ii) Use of healthcare resources, i.e. whether risk taking is affected by fear of overuse or fear of delayed diagnosis. iii) Use of patient resources, i.e. whether risk taking is affected by fear for unnecessary distress or need for necessary investigation to find those with cancer in an early stage.
GP self-assessed readiness to refer is defined as the proportion of hypothetical patients referred at their first presentation based on GP responses to patient scenarios (vignettes) concerning cancer diagnosis. 4) GP-assessed risk of cancer for referred patients. 5) Referred patients’ GP visit rates 6 months prior to diagnosis compared with their earlier use of general practice. 6) The proportion of patients with cancer among referred patients for each GP (GP’s PPV for diagnosing cancer when a patient is referred to the cancer fast-track pathway). 7) Cancer patients’ clinical tumour stage at the time of initiating treatment. 8) Cancer patients’ one-year survival measured as the proportion of cancer patients per GP alive one year after the date of diagnosis (Figure 3).
Data are collected by GP-completed online questionnaires before and after the CME and by GP-completed one-page forms on each patient referred to cancer investigation within an 8-month period surrounding the CMEs. These data will be expanded with register data.
Online questionnaire: Development, pilot testing and data collection
The online questionnaire consisted of vignettes and direct questions. The vignettes were validated and tested in the ICBP module-3 studies . They were developed to describe the likely GP actions which included GP readiness to refer when a patient presented with symptoms suggestive of lung cancer (two vignettes), colorectal cancer (two vignettes) or ovarian cancer (one vignette). GPs were asked to complete two randomly chosen vignettes. Each vignette had two or three phases: phase one represented the first patient presentation; phases two and three represented subsequent visits where the patient’s symptoms had developed; each phase had a defined PPV for cancer.
The direct questions were based on the elements of the CME developed as ad hoc questions to measure a possible CME effect on knowledge (6 items) and attitude (13 items). The first version of the questionnaire was developed by the authors and academic GPs in an iterative process that focused on the specific elements for CME intervention. The questionnaire was piloted for cognitive understanding among six doctors and, finally, among 12 GPs. Data quality, missing variables, and ceiling and floor effects were checked, and a revised version of the questionnaire was produced (Additional file 1).
The GPs were allocated a CME date. The invitation to the online questionnaire was sent by e-mail to the GPs 1 month before the CME. Non-responders received a reminder by e-mail after two weeks. A second questionnaire similar to the first one except for two new randomly selected vignettes was sent by e-mail 7 months after the CME to GPs who responded to the first questionnaire. Non-responders were reminded by e-mail after two weeks.
One-page forms on referred patients: Development, pilot testing, and data collection
This form was used to collect specific clinical information on patients referred from GPs to the fast-track pathway on cancer suspicion. The one-page form requested the patient’s personal identification number, the date of hospital referral, the date of first presentation of symptoms in general practice related to cancer suspicion, the symptoms presented at the time of referral, the specific fast-track pathway, and the GP’s assessment of the patient’s risk of cancer. GPs were asked to rate a specific risk for cancer by indicating a probability percentage (0–100) (Additional file 2).
All the items mentioned above have previously been validated in studies performed by the Research Unit ,. The form was piloted in three steps. Seven GP trainees were observed while they filled in the form about the most recent patient they had referred on cancer suspicion. They were interviewed about any problems encountered and how they understood the items. Three GPs then completed forms in their daily practice over a 2-week period in order to check its feasibility. Finally, 21 GPs were asked to fill out and subsequently send the forms electronically to the Research Unit to verify the feasibility of the electronic transfer and the optical scanning of the forms .
In August 2012, all GPs in the Central Denmark Region received a pad with 25 forms. They were requested to complete a form each time they referred a patient to a cancer fast-track pathway within an 8-month period (September 2012-May 2013). Patients referred to fast track were also identified in a regional database (PAS) and in a radiological database (breast cancer). If the GP form was missing, the GP was sent a form for the particular patient and kindly requested to complete it. This form was extended with an item on the patient’s route into a fast-track pathway investigation to include only patients referred from GPs on cancer suspicion (Additional file 3).
The one-page form was designed and processed in the computer programme Teleform Enterprise Version 8.0 (Cardiff software Inc., San Marcos, CA, USA). Handwritten data including presenting symptoms were coded by the first author (BST) before scanning .
All data will be transferred to the statistical program Stata (Stata software, version 11.1, StataCorp, College Station, Tex, USA) and will be checked for errors. If errors are encountered, the original form of the completed questionnaire will be inspected, and the database entry will be corrected.
Remuneration was 33 Euros for completing the first online questionnaire and 17 Euros for completing the second online questionnaire. The GPs received 100 Euros for completion of forms on referred patients during the 8-month period.
Each inhabitant with a permanent residence in Denmark has a 10-digit personal identification number, the CPR number. This number is registered in the Danish Civil Registration System and allows linkage between all national registries at the individual level. A cancer patient’s vital status will be obtained 12 months after the date of diagnosis.
The provider number registry contains the names and addresses of every Danish GP, the number of GPs in each general practice, and patient list size including the patients’ sex and age.
The Primary Care Referral Registry (an online database) stores copies of all electronic referral letters sent from general practice to hospital. We will develop an algorithm to identify patients referred on cancer suspicion in the 8-month study period to increase the completeness of the data on referred patients.
The Danish National Patient Registry  will be used to obtain information about comorbidity and cancer diagnoses.
The Danish National Health Service Registry  will be used to count the number of contacts of referred patients to general practice during the 6 months preceding the referral date. Each patients previous use of general practice patient will be counted and serve as a basis for comparison.
The Danish Cancer Registry  will be used to identify patients with cancer among all referred patients. From this registry, we will also obtain data on date of diagnosis, cancer type and tumour stage.
For the descriptive part, differences will be tested using appropriate parametric and nonparametric statistics. The effect of the intervention will be analysed in a generalised, linear, random-effects model with random effect of GPs. The data will be used to assess whether further modelling of inter-correlation within practice and within clusters is required, and whether the intervention effects are equal for all GPs or in random interaction with them. Analyses will be performed both in the full GP population "intention to intervene" (cluster level) and in the three GP subgroups: 1) GPs who participated in the CME, 2) GPs who did not participate in the CME, but had at least one colleague who participated, and 3) GPs who did not participate in the CME and who had no colleagues who participated. A colleague is defined as a GP with the same clinic address as the respondent. The intervention effect on GP knowledge and attitude will be measured in a before-after analysis.
Power calculation is based on the primary outcome: Primary care interval. The sample size is calculated to detect a reduction in the longest primary care intervals >20 days  from 25% to 20%. The expected effect is reduced according to an intervention to intervene analysis; we expect a GP participation rate at the CME-meetings of 40%. Uncorrected for clustering and repeated measures, a total sample size (N) of 5116 patients would be required (power of 99% and significance level of 0.05).
To accommodate the stepped wedge clustering effect N has to be multiplied by the design effect (DE) : N sw ?=?DE*N, where
Here, ? is the intra-cluster correlation, k is the number of steps, n is the average cluster size, b is the number of baseline measurements and t is the number of measurements after each step. In our study k = 8, b = t = 1. Furthermore, we assume that ? = 0.05, as it is a typical value for intra-cluster correlation for clinical outcomes in primary care . The cluster size can be expressed as n = N sw / c, where c is the number of clusters. The number of clusters is known in advance (c = 8) and the question is how many subjects per cluster should be sampled to provide the power required. Using the equations described above, this cluster size is estimated as n = 200 through an iterative procedure. Therefore, the total sample required (N sw) is 1,653. In Central Denmark Region, 5,400 new cancer patients are expected in an 8-month period. We assumed that 40%  of those (2,200) will be referred from general practice to a cancer fast-track pathway. With an assumed PPV for diagnosing cancer in fast-track pathway on 20% and an assumed GP response rate on 70%, we expect to receive one-page forms with information on primary care intervals on 7,700 patients. Thus, it is considered that the study has ample strength—also in relation to three stratified subgroups of GPs and adjustment for multiple predictors.
The Danish Research Ethics Committee (j.no. 10/2014) concluded that no approval is necessary. The study was approved by the Danish Data Protection Agency (j.no. 2009-41-3471). The Danish National Board of Health gave legal permission to obtain information from the GPs’ medical records without permission from the patients (j.no. 3-3013-149/1/HKR). The regional Data Protection Agency gave permission to use the regional database (PAS) and the radiological database to obtain information on patients investigated in a cancer fast-track pathway (j.no. 1-16-02-262-12). The study is registered as NCT02069470 on ClinicalTrials.gov.
The study is ongoing. The CME meetings were conducted in the period September 2012 to May 2013. We have not yet conducted data cleaning or obtained data from registers; only the data from forms and questionnaires have been collected. Furthermore, we have not yet developed the algorithm to identify referred patients from the Primary Care Referral Registry.
We developed a multifaceted CME in early cancer diagnosis targeting the individual GPs using a step-wise approach for the development of complex interventions . We identified key elements and analysed them by using the COM-B system described by Michie et al. . The effect evaluation will be conducted in a geographical cluster randomised stepped wedge study. The effect of the CME will be measured at three levels: GP knowledge and attitude, GP activity and patient outcomes.
Strengths and limitations of the study
With a detailed description of the CME elements, training process and context, we have tried to optimise the possibilities for an adaptation/replication in other settings.
The time frame of the present study did not afford us with the possibility to conduct an explorative study on the target group before the trial; instead, a full-scale CME was conducted in an external regional cancer steering group, and the findings were subsequently evaluated, discussed and approved.
Randomising individual GPs to the CME intervention was considered unfeasible as much of the effect would include GPs working together and discussing cancer diagnosis within practices and in the CME groups. Preventing GPs from participation was considered unethical since the CME was a part of the Danish Cancer Plan, and it was considered important that all patients could benefit from an improved clinical practice. A cluster randomised stepped wedge study was thus preferred. Using this design, we will be able to control for time trends by allowing contemporaneous comparisons across clusters at different time periods.
Designing a study in real life, however, raised some challenges with regard to controlling the intervention. A specific CME date was offered to all GPs, but they were free to decide whether they wanted to participate or not. The collected data will allow us to compare the three GP subgroups of each cluster at a baseline level to explore potential selection bias.
GP knowledge, attitude and self-assessed readiness to refer will be measured by online questionnaires before and after the CME to allow paired analyses to be performed. The GPs were informed in the invitation letter that the questionnaire attempted to measure activity related to cancer diagnosis in general practice. This could have influenced the responses.
By placing a pad with forms in each GP office and by sending regular reminders (every second week), we expect to collect prospective data, i.e. to obtain data before the GPs know whether the referred patient had cancer or not. In cases where the GP forgot to complete a form and had to be requested to do so, information bias can occur. Furthermore, lead time bias will be considered when reporting the 1-year survival. This outcome will be evaluated in close relation to potential change in cancer stage.
We have developed a theory-based CME in early cancer diagnosis. We have described the CME to allow our intervention to be replicated. We have outlined the geographical cluster randomised stepped wedge design chosen for measuring the effect of the CME. If the CME has an impact on the chosen outcomes, the model used for its development may be used in similar primary health care setting.
BST led the coordination and the conceptualisation of the study supported and coached by PV and FB. All authors formed the research group which identified the barriers. BST wrote the first draft of the article, PV and FB critically reviewed it and provided comments to improve the manuscript. All authors read and approved the final manuscript.
BST is a medical doctor, a general practitioner and a PhD Fellow. She is employed at the Research Centre for Cancer Diagnosis in Primary Care (CaP), Research Unit for General Practice, Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000 Aarhus C, Denmark. FB is a PhD degree holder, a medical doctor, a general practitioner, a professor and Head of the Research Unit for General Practice, Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000 Aarhus C, Denmark. PV is a PhD degree holder, a medical doctor, a professor and Head of Research Centre for Cancer Diagnosis in Primary Care (CaP), Research Unit for General Practice, Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000 Aarhus C, Denmark.
Continuing Medical Education
- COM-B System:
A behavioural system involving three essential conditions, capability, opportunity and motivation
Positive predictive value
International Cancer Benchmarking Partnership
Danish Civil Registration System
The Danish National Patient Registry
The Danish National Health Service Registry
The Danish Cancer Registry
Patients administrative system
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We thank hospital-GP liaison advisors Rikke Pilegaard and Jens Rubak, CME supervisor Marianne Lentz and regional academic coordinator Gry Stie for contribution with the operationalisation of the CME program.
We thank data manager Kaare Rud Flarup for creating the database; statistician Alina Zalounina Falborg for assistance; Director of Operations at Sigmer Technologies John Archibald for designing the online questionnaire; ICBP Central Team for reuse of the vignettes (patient scenarios). Furthermore we thank Anne Gammelgaard from Quality and informatics, Central Denmark Region and the four radiological departments in Aarhus, Holstebro, Randers and Viborg for data on patients referred to a fast-track pathway.
The project was supported by the Fund for Research in General Practice, the Committee for Quality Improvement and Continuing Medical Education (KEU) of the Central Denmark Region, the Multi-Practice Committee (MPU) of the Danish College of General Practitioners (DSAM), the Danish Cancer Research Foundation, the Danish Cancer Society and the Novo Nordisk Foundation. The sponsoring organisations were not involved in any part of the study.
PV was lecturer at seven CME meetings; FB was lecturer at one CME meeting. The authors declare that they have no competing interests.
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Additional file 1: The ad hoc questions developed to measure a possible CME effect on GP knowledge and GP attitude.(PDF 91 KB)
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Toftegaard, B.S., Bro, F. & Vedsted, P. A geographical cluster randomised stepped wedge study of continuing medical education and cancer diagnosis in general practice. Implementation Sci 9, 159 (2014). https://doi.org/10.1186/s13012-014-0159-z
- General Practice
- Continuing Medical Education
- Early Detection of Cancer