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Explaining the effects of an intervention designed to promote evidence-based diabetes care: a theory-based process evaluation of a pragmatic cluster randomised controlled trial
© Francis et al; licensee BioMed Central Ltd. 2008
Received: 01 May 2006
Accepted: 19 November 2008
Published: 19 November 2008
The results of randomised controlled trials can be usefully illuminated by studies of the processes by which they achieve their effects. The Theory of Planned Behaviour (TPB) offers a framework for conducting such studies. This study used TPB to explore the observed effects in a pragmatic cluster randomised controlled trial of a structured recall and prompting intervention to increase evidence-based diabetes care that was conducted in three Primary Care Trusts in England.
All general practitioners and nurses in practices involved in the trial were sent a postal questionnaire at the end of the intervention period, based on the TPB (predictor variables: attitude; subjective norm; perceived behavioural control, or PBC). It focussed on three clinical behaviours recommended in diabetes care: measuring blood pressure; inspecting feet; and prescribing statins. Multivariate analyses of variance and multiple regression analyses were used to explore changes in cognitions and thereby better understand trial effects.
Fifty-nine general medical practitioners and 53 practice nurses (intervention: n = 55, 41.98% of trial participants; control: n = 57, 38.26% of trial participants) completed the questionnaire. There were no differences between groups in mean scores for attitudes, subjective norms, PBC or intentions. Control group clinicians had 'normatively-driven' intentions (i.e., related to subjective norm scores), whereas intervention group clinicians had 'attitudinally-driven' intentions (i.e., related to attitude scores) for foot inspection and statin prescription. After controlling for effects of the three predictor variables, this group difference was significant for foot inspection behaviour (trial group × attitude interaction, beta = 0.72, p < 0.05; trial group × subjective norm interaction, beta = -0.65, p < 0.05).
Attitudinally-driven intentions are proposed to be more consistently translated into action than normatively-driven intentions. This proposition was supported by the findings, thus offering an interpretation of the trial effects. This analytic approach demonstrates the potential of the TPB to explain trial effects in terms of different relationships between variables rather than differences in mean scores. This study illustrates the use of theory-based process evaluation to uncover processes underlying change in implementation trials.
There is broad, international agreement over what constitutes high quality health care for people with diabetes [1, 2]. In the UK, this has been enshrined in a National Service Framework for people with diabetes . However, the most efficient method of delivering care remains unclear . A recent systematic review  of quality improvement interventions to improve the quality of care in patients with diabetes showed that a range of different interventions resulted in small to modest improvements in glycaemic control and in provider adherence to optimal care. However it also identified important methodological concerns, including evidence of publication bias.
Given the variety of possibly effective interventions, it may be instructive to focus on possible mechanisms underlying intervention effects, with the goal of identifying how such interventions may work. This type of process evaluation can lead to the identification of general principles that will help to optimise interventions. The study reported here was a theory-based process evaluation of a pragmatic cluster randomised controlled trial design. The trial evaluated the effectiveness and efficiency of an area wide 'extended' computerised diabetes register incorporating a full structured recall and management system, actively involving patients and including individualised patient management prompts to primary care clinicians based on locally-adapted evidence-based guidelines.
Three Primary Care Trusts (PCTs) (geographically based organisational units that are directly responsible for health care) served by a district hospital-based diabetes register had produced improvements in the quality of care, but performance had later plateaued leaving scope for further improvement. The opportunity arose to extend the computerised diabetes register to a full structured recall and management system.
The development and implementation of the Diabetes Recall and Management System (DREAM) intervention has been described in detail elsewhere [5, 6]. In summary, the pre-existing diabetes register functioned as a central register of patients with diabetes. A structured dataset was completed on paper forms and returned to the central register; from these data, both patient-specific and aggregated information were provided annually to patients and clinicians. This system was enhanced in five ways. The software was enhanced by incorporating locally adapted national evidence-based guidelines. The functionality of the system was enhanced to provide: automated prompts to patients and primary care clinicians that a review consultation was necessary; a structured management sheet (including patient-specific management suggestions); an enhanced monitoring system to follow up reasons for non-attendance from both patients and clinicians and to re-schedule appointments, based on non-return of a completed management sheet; and patient feedback for patients in primary care. Because of difficulties operating this element of the software, it was not possible to run the final feature during the lifetime of the trial.
Quality control, fidelity, or coverage (i.e., was the intervention successfully and consistently implemented?).
Acceptability of the intervention from the participants' perspective.
Explanatory modelling: an exploration of processes underlying change (or lack of change) following a successfully implemented intervention.
The TPB is predicated on careful specification of the behaviour under investigation. The behaviour is defined in terms of its target, action, context and time (TACT). For example, for the clinical behaviour of measuring a patient's blood pressure, the target is the patient; the action is taking the blood pressure reading; the context is the clinical consultation; and the time may be expressed in terms of frequency (e.g., every time the patient visits the surgery; at least once every six months) or delay (e.g., at the patient's next routine visit to the surgery; within the next six months). In the current study, three behaviours were identified from the clinical guidelines used in the DREAM Trial as being central in the management of Type 2 diabetes: measuring blood pressure, inspecting feet, and prescribing statins (to lower cholesterol). As data about actual behaviour were not available at the level of the individual clinician (but only at the level of primary care practices), we used the measure of intention as the dependent variable for this process evaluation. A recent systematic review concluded that intention is an appropriate proxy measure of individual behaviour .
The findings of the trial are reported elsewhere , but the findings relevant to these three behaviours were: first, patients in intervention practices were significantly more likely than patients in control practices to have a recording of having had either a foot check or a measurement of blood pressure but not a measurement of serum cholesterol; and second, the mean cholesterol level in patients from intervention practices was significantly lower than in control practices, but there was no difference between intervention and control groups in the levels of blood pressure recorded.
The aim of this study was to elucidate the cognitions of health professionals that underlay these selected clinical behaviours. We did this in two ways: first, by testing for differences in cognitions between the intervention and control groups of the trial and second, by identifying the patterns of association within each trial group and comparing these with effects of the intervention on clinical practice .
Development of the questionnaire
The three 'predictor' variables in the TPB are attitudes (being in favour of, or against doing something); subjective norms (perceived pressure from social sources to do, or not to do something); perceived behavioural control, or PBC (perception of having, or not having control over the behaviour). They may be measured 'directly' by asking responders to summarise their overall attitude, perceived pressure and so on, or 'indirectly', by asking responders about specific beliefs and combining the answers in a manner specified by the theory . According to the TPB, when using direct measures in a regression analysis to predict intention, adding the indirect measures should not increase the level of prediction. However, we included both measures in the questionnaire to test this part of the theory, because direct and indirect measurement approaches make different assumptions about the underlying cognitive structures . Briefly, indirect measures are based on responses to items about specific beliefs and scores are then combined by the researcher. The assumptions are that the method used for combining responses (weighting and then averaging the scores) reflects the methods that individuals use when forming, for example, an attitude, and that all relevant beliefs have been represented among the questionnaire items. Direct measurement effectively asks individuals themselves to combine the separate beliefs. It does not rely on the assumption that all relevant beliefs have been represented in the questionnaire but assumes that people can accurately combine and report a global attitude, subjective norm, and perceived level of control over the behaviour in question. The construction of the measures of the three predictor variables and of intention was based on standard practice in the field including the advice of researchers [7, 11–13].
To construct the indirect measures we first conducted a qualitative study. A member of the research team (LS) interviewed 12 general practitioners (GPs) and practice nurses not involved in the DREAM trial about the behaviours under investigation. We designed the schedule for these semi-structured interviews to elicit responders' beliefs relating to the constructs of the TPB. Both GPs and practice nurses were encouraged to talk freely about these beliefs, and any ambiguities were clarified using appropriate prompts. Interviews were tape recorded and transcribed. Answers to questions were entered into response tables. We identified the most frequently mentioned beliefs and used them to develop items for indirect measurement of the three predictor variables.
Sample questionnaire items for the constructs relating to measuring blood pressure.
Overall I think measuring these patients' blood pressure is beneficial to them
(If I measure a patient's blood pressure, I will detect any problems at an early stage) × (Detecting any problems at an early stage is very important)
Subjective norm (direct)
People who are important to me think that I should measure the blood pressure of my patients with diabetes
Subjective norm (indirect)
(Patients would approve of me measuring their blood pressure) × (Patients' approval of my practice is of importance to me)
Perceived behavioural control (direct)
Measuring patients' blood pressure is easy
Perceived behavioural control (indirect)
(If the patient has high blood pressure they think they have another illness as well as diabetes) × (If the patients did not see raised blood pressure as a separate illness to diabetes I would be more likely to measure their blood pressure)
I intend to measure the blood pressure of most of the patients' with diabetes that I see during the next month
The questionnaire was mailed to all 280 GPs and practice nurses in the DREAM trial. Two reminder letters were sent to non-responders at fortnightly intervals.
Psychometric properties of the questionnaire
Internal consistency coefficients were calculated for the intention measure and for the direct measure of attitude, for each of the three behaviours. Coefficient alpha was satisfactory (between 0.87 and 0.98). Direct measures of subjective norm and perceived behaviour control were two-item measures, and so consistency was assessed using Pearson's correlation coefficients. Using a criterion for acceptability of r > 0.25, internal consistency was high (r > 0.4) for the measures of subjective norms and mixed (two coefficients close to zero) for the measures of PBC. It is not appropriate to use an internal consistency criterion for assessing the reliability of indirect measures, as the objective in using these measures is to sample a diverse range of beliefs .
Because the two PBC items did not have adequate internal consistency, it was not valid to combine these scores for the main analysis. We selected one item ('Overall, I feel that I can [do X]') to represent PBC for the analysis as it was more consistently related to the other TPB variables across the three behaviours.
Indirect measures were computed using the 'multiplicative composite' approach suggested by Ajzen and Fishbein . That is, the score for each belief was multiplied by the score of its perceived importance weight (see Figure 1) and the resulting products were summed to give a total score for attitude, subjective norms, and PBC for each of the three behaviours. For direct and indirect measures, scores were scaled so that a low score always indicated a more positive attitude, intention, etc.
There is considerable debate in the TPB literature about whether to use response scales of 1 to 7 or -3 to +3 in the multiplicative composite approach (e.g., French and Hankins ). As the questionnaire was lengthy, we decided, on a pragmatic basis, to use a consistent 1–7 response format to minimise responder fatigue.
Chi-square analyses of responders showed no association between trial group (intervention versus control) and the following variables: diabetes register, number of GPs in the practice, number of nurses in the practice, prescribing status of nurses, and years since qualified (all p > 0.3). Nevertheless, as this was a process evaluation of a trial, the remaining descriptive analyses were conducted separately for intervention and control participants.
Means, standard deviations (SD), and correlations between the predictor variables (direct measures) and intention scores and indirect measures, for each of the three behaviours, computed separately for the intervention and control groups.
Control Group: Direct Measures
Intervention group: Direct Measures
Measuring Blood Pressure
Group differences in TPB variables: Multiple analyses of variance (MANOVAs)
To identify factors affecting the mean values of the TPB variables, a series of MANOVAs were conducted. For each of the three behaviours under investigation, intention and direct measure scores for the three predictor variables were entered as dependent variables. Three designs were used:
Trial group (intervention; control) × job title (GP; nurse) × PCT)
Trial group (intervention; control) × practice size (< 4 GPs; ≥ 4 GPs)
Trial group (intervention; control) × years since qualified (≤ 23 years; > 23 years)
There was no main effect of trial group and no interaction effects involving trial group on the profile of TPB scores. That is, the intervention appears to have had no effect on scores for attitudes, subjective norms, PBC, or intentions. However, there was a main effect of practice size on intentions. Responders (both GPs and nurses) in smaller practices had stronger intentions to measure blood pressure. In addition, there was a main effect of job title (GP; nurse) on cognitions. Nurses had more positive intentions and attitudes than GPs for measuring BP and examining feet. The pattern for statins was reversed, with GPs reporting stronger intentions, more positive attitudes, and also greater PBC than nurses. This again lends support to the criterion validity of the PBC item, as it would be expected that nurses, most of whom are not eligible to prescribe, would report lower control over prescribing behaviour. No other main effects or interaction effects were significant in the MANOVAs.
Predicting intention: Regression analyses
Results of regression analyses on intentions for three behaviours, with direct measures entered at Step 1 and indirect measures entered at Step 2, for control and intervention groups.
Intention to measure blood pressure
Intention to inspect feet
Intention to prescribe statins
Intention to measure blood pressure
Intention to inspect feet
Intention to prescribe statins
We performed a second series of hierarchical regression analyses, with professional (GP or nurse) and practice size (< 4 GPs; ≥ 4 GPs) entered at the first step and the direct TPB measures entered at the second step. After controlling for job title and practice size, the TPB predictor variables again significantly added to the variance in intention explained, and the patterns of significant predictors were similar to the first set of analyses. This finding was consistent in both the control and intervention group for all three behaviours.
Interpreting trial effects
Results of regression analyses (n = 112) on intentions to inspect feet and intentions to prescribe statins, with direct measures entered at Step 1 and the interaction between direct measures and trial group entered at Step 2.
Intention to inspect feet
Subjective Norm (SN)
Trial group × Attitude
Trial group × SN
Intention to prescribe statins
This study was a theory-based process evaluation undertaken to investigate the cognitive processes underlying trial effects. In addition, extraneous variables that may affect clinicians' cognitions and behaviour were investigated, and patterns of clinical behaviours were explored. Results are discussed below in four sections: trial effects; effects of demographic factors on cognitions about clinical behaviours; limitations of the study; and general conclusions.
In the context of the effect of interventions on cognitive variables, there are two possible types of effect. First, an intervention may alter the mean values of scores on predictor variables. Second, an intervention may alter the relationships between the cognitive predictor variables and an outcome, in this case, intentions. It appears that the effect of the intervention in the DREAM trial was of the second kind. With respect to inspecting feet, subjective norms were more strongly related to intention in the control group than in the intervention group, and attitudes were more strongly related to intention in the intervention group than in the control group. Thus, at the end of the intervention, intentions to inspect feet were 'normatively-driven' in the control group but 'attitudinally-driven' in the intervention group.
There are a number of possible explanations for how the intervention might have strengthened the attitude-intention relationship. It could be that clinicians became more familiar with the content of the guideline by receiving the intervention, and that this familiarity (or additional knowledge) strengthened the consistency between attitudes and intentions. In addition, when attitudes are based on direct experience, they are more likely to be brought to mind in the relevant context . Furthermore, it may be that the systematic application of the guideline in terms of prompts relating to specific patients made the importance of key clinical indicators more salient. For all of these possibilities, attitudes would supersede subjective norms as the primary predictor of intentions.
There is empirical evidence that attitudinally-driven intentions are more likely to be translated into action than normatively-driven intentions [16–18]. This has been explained by reference to self-determination theory , which distinguishes between self-determined (or intrinsically motivated) and externally controlled regulation of intention. Within this framework, attitudes represent internal pressure (one's own views), whereas subjective norms represent external pressure (the perceived views of others), to act. Self-determination theory proposes that internalised motivation is related to the stability of intentions and is a better predictor of behaviour than motivation arising from external sources [20, 21].
The implication of this in the context of the DREAM trial is as follows. On the basis of these findings, we would expect higher levels of foot inspection to be recorded in the intervention group than in the control group. This is what was found in the trial. Thus, the results of the current study support the principle that attitudinally-driven intentions are better translated into action than are normatively-driven intentions. A further key trial effect (lowered cholesterol among participants in the intervention group) was possibly related to the trend (albeit non-significant in our analysis) for statin prescription also to be attitudinally-driven (i.e., internally motivated) in the intervention group.
A strength of this study was that we investigated three behaviours among the same population at the same time. This enabled us to compare and contrast patterns of prediction across the behaviours. The three selected behaviours were strongly contrasting: the measurement of blood pressure is a frequently enacted behaviour (intention data in this study showed restricted range and possible ceiling effects); the inspection of feet is a clinical action that both physicians and their practice nurses are qualified to do (although our data showed that cognitions of the two professional groups tend to be different); and the prescription of statins is restricted to physicians and a small proportion of nurses. Yet the TPB was effective in predicting intentions to do these contrasting behaviours, suggesting that the model was stable across a range of behaviours
Effects of demographic factors
Demographic factors appeared to affect cognitions about clinical behaviours. As may be expected from the different responsibilities assigned to different roles, professional role (GP versus nurse) influenced cognitions. Nurses had stronger positive attitudes and intentions to measure blood pressure and inspect feet, whereas for prescribing statins, GPs had stronger attitudes, perceived control, and intentions. This would be expected and supports the validity of the measurement instruments.
A further demographic effect was practice size. In smaller practices, GPs and nurses had stronger intentions to measure blood pressure, and GPs had stronger intentions to prescribe statins. This is consistent with the results of a previous trial that tested the effects of educational outreach in a primary care setting , and suggests that a fruitful approach to exploring the implementation of evidence-based practice could include an investigation of organisational factors in relation to practice size.
This study had a number of limitations. First, although the non-response analysis indicated that the sample was representative in all but one of the measured variables (number of years since professional qualification), the response rate was low (40% at the individual level; 81% at the practice level). It is also possible that some responders were completing the questionnaire on behalf of other practice staff and this would introduce measurement error. Second, the items measuring PBC had poor psychometric properties, and so their reliability is uncertain. Third, TPB constructs were measured only once – after the intervention. However, randomisation of primary care practices to the intervention and control groups in the trial should have resulted in similar cognitions between groups before the intervention took place. Finally, as the process evaluation study sampled only three clinical behaviours out of all the appropriate behaviours relating to this complex intervention, there may have been other mechanisms underlying trial effects that were not detected by this study. For example, it may have been that the automated prompts to patients and clinicians regarding the need for a review consultation resulted in increased concordance in interactions between patients and clinicians and that this increased patients' involvement in the management of their condition.
This theory-based process evaluation of the DREAM trial explored cognitions about three clinical behaviours relating to the management of diabetes to identify possible effects of the trial intervention on cognitions, including intentions. Independently of whether participants were in the intervention group or control group, professional role and practice size influenced attitudes, PBC, and intentions. This suggests that interventions that are directed to entire practices or health care teams may have different effects on individuals within those teams and across different organisational structures. Finally, it appears that the intervention strengthened the link between attitudes and intentions towards inspecting feet, with similar non-significant trends in cognitions about prescribing statins. This stronger link between internal pressures (attitudes) and intentions than between external pressures (subjective norms) and intentions was associated with trial outcomes. This lends support to the principle that when intentions are driven by attitudes rather than perceived social pressure, those intentions are more likely to be translated into action. Thus, understanding the difference between attitudes and subjective norms allowed us to understand some of the intervention effects. This study thus illustrates the use of theory-based process evaluation to uncover processes underlying change in implementation trials.
We are grateful to the health care professionals who participated in this study.
This project was funded by the European Union as part of the ReBEQI project http://www.rebeqi.org. Jeremy Grimshaw holds a Canada Research Chair in Health Knowledge Transfer and Uptake. Eileen Kaner holds a Department of Health funded NHS Primary Care Career Scientist award.
- The Acropolis Affirmation: Diabetes Care – St Vincent in Progress. Statement from the Saint Vincent Declaration meeting, Athens, Greece, march 1995. Diabetic Med. 1995, 12: 636-View ArticleGoogle Scholar
- UK Prospective Diabetes Study (UKPDS) Group: Intensive blood-glucose control with sulphonylureas or insulin compared to conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998, 352: 837-853. 10.1016/S0140-6736(98)07019-6.View ArticleGoogle Scholar
- Department of Health: National Service Framework for Diabetes: Delivery Strategy. 2003, London: Department of HealthGoogle Scholar
- Shojania KG, Ranji SR, Shaw LK, Charo LN, Lai JC, Rushakoff RJ, Owens DK: Diabetes Mellitus Care. Closing the Quality Gap: a critical analysis of quality improvement strategies. Technical review 9. Edited by: Shojania KG, McDonald KM, Wachter RM, Owens DK. 2004, Rockville, MD: Agency for Healthcare Research and Quality, 2:Google Scholar
- Eccles M, Hawthorne G, Whitty P, Steen N, Vanoli A, Grimshaw J, Wood L: A randomised controlled trial of a patient based Diabetes Recall and Management System: the DREAM trial: A study protocol [ISRCTN32042030]. BMC Health Services Research. 2002, 2: 5-10.1186/1472-6963-2-5.View ArticlePubMedPubMed CentralGoogle Scholar
- Whitty P, Eccles MP, Hawthorne G, Steen N, Vanoli A, Grimshaw JM, Wood L, Speed C, McDowell D: Improving services for people with diabetes: lessons from setting up the DREAM trial. Practical Diabetes International. 2004, 21: 323-328. 10.1002/pdi.711.View ArticleGoogle Scholar
- Ajzen I: The Theory of Planned Behavior. Organ Behav Hum Decis Process. 1991, 50: 179-211. 10.1016/0749-5978(91)90020-T.View ArticleGoogle Scholar
- Walker AE, Grimshaw JM, Armstrong E: Salient beliefs and intentions to prescribe antibiotics for patients with a sore throat. British Journal of Health Psychology. 2001, 6: 347-360. 10.1348/135910701169250.View ArticlePubMedGoogle Scholar
- Eccles MP, Hrisos S, Francis J, Kaner E, Dickinson HO, Beyer F, Johnston M: Do self-reported intentions predict clinicians' behaviour: a systematic review. Implement Sci. 2006, 1: 28-10.1186/1748-5908-1-28.View ArticlePubMedPubMed CentralGoogle Scholar
- Eccles MP, Hawthorne G, Whitty P, Steen N, Vanoli A, Grimshaw JM, Wood L: A cluster randomised controlled trial of a Diabetes Recall and Management system: the DREAM trial. Centre for Health Services Research Report No. 113. 2006, University of Newcastle upon Tyne: Centre for Health Services ResearchGoogle Scholar
- Francis JJ, Eccles MP, Johnston M, Walker AE, Grimshaw JM, Foy R, Kaner EFS, Smith L, Bonetti D: Constructing questionnaires based on the theory of planned behaviour. A manual for health services researchers. 2004, University of Newcastle upon Tyne: Centre for Health Services ResearchGoogle Scholar
- Godin G, Kok R: The Theory of Planned Behaviour: A Review of Its Applications to Health-related Behaviours. American Journal of Health Promotion. 1996, 11: 87-98.View ArticlePubMedGoogle Scholar
- Ajzen I, Fishbein M: Understanding attitudes and predicting social behaviour. 1980, Englewood Cliffs, New Jersey: Prentice-HallGoogle Scholar
- French DP, Hankins M: The expectancy-value muddle in the theory of planned behaviour – and some proposed solutions. British Journal of Health Psychology. 2003, 8: 37-55. 10.1348/135910703762879192.View ArticlePubMedGoogle Scholar
- Fazio RH, Chen J, McDonel EC, Sherman SJ: Attitude-accessibility, attitude-behavior consistency, and the strength of the object-evaluation association. Journal of Experimental Social Psychology. 1982, 18: 339-57. 10.1016/0022-1031(82)90058-0.View ArticleGoogle Scholar
- Ajzen I, Fishbein M: Attitude and the Attitude-Behavior Relation: Reasoned and Automatic Processes. European Review of Social Psychology. Edited by: Stroebe W, Hewstone M. 2001, New York: John Wiley & Sons, 1-33.Google Scholar
- Cooke R, Sheeran P: Moderation of cognition-intention and cognition-behaviour relations: a meta-analysis of properties of variables from the theory of planned behaviour. Br J Soc Psychol. 2004, 43: 159-186. 10.1348/0144666041501688.View ArticlePubMedGoogle Scholar
- Sheeran P, Norman P, Orbell S: Evidence that intentions based on attitudes better predict behaviour than intentions based on subjective norms. European Journal of Social Psychology. 1999, 29: 403-406. 10.1002/(SICI)1099-0992(199903/05)29:2/3<403::AID-EJSP942>3.0.CO;2-A.View ArticleGoogle Scholar
- Deci EL, Ryan RM: Intrinsic motivation and self-determination in human behaviour. 1985, New York: PlenumView ArticleGoogle Scholar
- Deci EL, Ryan RM: The "what" and "why" of goal pursuits: Human needs and the self-determination of behavior. Psychological Inquiry. 2000, 11: 227-268. 10.1207/S15327965PLI1104_01.View ArticleGoogle Scholar
- Chatzisarantis NLD, Biddle SJH: Functional significance of psychological variables that are included in the theory of planned behaviour: A self-determination theory approach to the study of attitudes, subjective norms, perceptions of control and intentions. European Journal of Social Psychology. 1998, 28: 303-322. 10.1002/(SICI)1099-0992(199805/06)28:3<303::AID-EJSP853>3.0.CO;2-6.View ArticleGoogle Scholar
- Freemantle N, Nazareth I, Eccles M, Wood J, Haines A, the Evidence-based OutReach (EBOR) Trialists: A randomised trial of the effect of educational outreach by community pharmacists on prescribing in the UK General Practice. British Journal of General Practice. 2002, 52: 290-295.PubMedPubMed CentralGoogle Scholar
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