Table 4 Criteria to be met for a recommendation for use of interventions in the context of research to be sensible

1. There must be important uncertainty about the effects of the intervention (e.g., low or very low quality evidence for either or both the desirable and undesirable consequences.

2. Further research must have the potential to reduce that uncertainty at a reasonable cost.

3. The potential benefits and savings of reducing the uncertainty outweigh the potential harms and costs of either using or not using the intervention based on currently available evidence