Behrens et al. 2002 [20]
|
Germany
|
Pre- and in-hospital
|
Uncontrolled before and after
|
63
|
1,5,9
|
3
|
9
|
1
|
86
|
57
|
10
|
2
|
Morgenstern et al. 2003 [21]
|
USA
|
Pre- and in-hospital
|
Parallel group trial
|
89
|
1,5,7,8,9
|
5
|
9
|
1
|
80
|
70
|
11
|
1
|
Lattimore et al. 2003 [22]
|
USA
|
In-hospital
|
Uncontrolled before and after
|
50
|
1,5,7,9
|
4
|
44
|
3
|
420
|
200
|
10
|
2
|
Belvis et al. 2005 [23]
|
Spain
|
Pre- and in-hospital
|
Parallel group trial
|
67
|
2,
|
1
|
7
|
8
|
37
|
181
|
19
|
4
|
Wojner-Alexandrov et al. 2005 [24]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
75
|
1,2,5,9,7
|
4
|
64
|
21
|
709
|
192
|
9
|
11
|
Ickenstein et al. 2005 [25]
|
Germany
|
In-hospital
|
Uncontrolled before and after
|
67
|
2,5,9,1,7
|
5
|
45
|
10
|
164
|
155
|
27
|
6
|
Nam et al. 2007 [26]
|
South Korea
|
In-hospital
|
Uncontrolled before and after
|
67
|
2,7,9
|
3
|
25
|
14
|
213
|
529
|
12
|
3
|
Demaerschalk et al. 2008 [27]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
71
|
1,9
|
2
|
320
|
4
|
1800
|
1454
|
18
|
0
|
Abdullah et al. 2008 [28]
|
USA
|
Pre- and in-hospital
|
Parallel group trial
|
79
|
2,
|
1
|
18
|
16
|
44
|
74
|
41
|
22
|
Quain et al. 2008 [29]
|
Australia
|
Pre- and in-hospital
|
Uncontrolled before and after
|
88
|
2,5,7,9
|
4
|
30
|
5
|
140
|
107
|
21
|
5
|
Gladstone et al. 2009 [30]
|
Canada
|
Pre- and in-hospital
|
Uncontrolled before and after
|
58
|
2,7,9
|
3
|
30
|
7
|
128
|
74
|
23
|
9
|
Pedrogosa et al. 2009 [31]
|
Spain
|
In-hospital
|
Uncontrolled before and after
|
71
|
2,9
|
2
|
19
|
9
|
198
|
201
|
10
|
4
|
Chenkin et al. 2009 [32]
|
Canada
|
Pre- and in-hospital
|
Uncontrolled before and after
|
79
|
5,2,9
|
3
|
56
|
18
|
554
|
307
|
10
|
6
|
Muller-Nordhorn et al. 2009 [33]
|
Germany
|
Pre-hospital
|
Randomised controlled trial
|
100
|
1,5
|
2
|
17
|
13
|
741
|
647
|
2
|
2
|
Kim et al. 2009 [34]
|
South Korea
|
Pre- and in-hospital
|
Uncontrolled before and after
|
71
|
2,9,7
|
3
|
47
|
44
|
328
|
678
|
14
|
6
|
Heo et al. 2010 [35]
|
South Korea
|
In-hospital
|
Uncontrolled before and after
|
71
|
7,9,2
|
3
|
312
|
199
|
5404
|
5798
|
6
|
3
|
Dharmasaroja et al. 2010 [36]
|
Thailand
|
In-hospital
|
Uncontrolled before and after
|
67
|
1,2,5,9
|
4
|
110
|
14
|
406
|
170
|
27
|
8
|
Bae et al. 2010 [37]
|
South Korea
|
Pre- and in-hospital
|
Parallel group trial
|
79
|
2,
|
1
|
33
|
18
|
55
|
47
|
60
|
38
|
Sung et al. 2011 [38]
|
Taiwan
|
In-hospital
|
Uncontrolled before and after
|
75
|
9,
|
1
|
21
|
40
|
139
|
338
|
15
|
12
|
Reiner-Deitemyer et al. 2011 [39]
|
Austria
|
Pre-hospital
|
Parallel group trial
|
63
|
9,
|
1
|
224
|
1062
|
898
|
13,731
|
25
|
8
|
Hoegerl et al. 2011 [40]
|
USA
|
In-hospital
|
Uncontrolled before and after
|
79
|
1,7,9
|
3
|
12
|
4
|
101
|
132
|
12
|
3
|
Etgen et al. 2011 [41]
|
Germany
|
In-hospital
|
Uncontrolled before and after
|
71
|
5,7,9,2
|
4
|
95
|
24
|
742
|
500
|
13
|
5
|
Walter et al. 2011 [42]
|
Germany
|
In-hospital
|
Uncontrolled before and after
|
79
|
9,7
|
2
|
16
|
32
|
78
|
120
|
21
|
27
|
Driks et al. 2011 [43]
|
Netherland
|
In-hospital
|
Randomised controlled trial
|
100
|
1,7,9
|
3
|
391
|
305
|
2990
|
2525
|
13
|
12
|
Addo et al. 2012 [44]
|
UK
|
Pre-hospital
|
Uncontrolled before and after
|
88
|
1,
|
1
|
45
|
55
|
274
|
326
|
16
|
17
|
Walter et al. 2012 [42]
|
Germany
|
Pre-hospital
|
Randomised controlled trial
|
100
|
9,7
|
2
|
12
|
8
|
53
|
47
|
23
|
17
|
O'Brien et al. 2012 [45]
|
Australia
|
Pre- and in-hospital
|
Uncontrolled before and after
|
67
|
1,2
|
2
|
22
|
5
|
115
|
67
|
19
|
7
|
Berglund et al. 2012 [46]
|
Sweden
|
Pre- and in-hospital
|
Randomised controlled trial
|
81
|
2,9
|
2
|
60
|
24
|
488
|
454
|
12
|
5
|
Prabhakaran et al. 2012 [47]
|
USA
|
In-hospital
|
Parallel group trial
|
71
|
9,
|
1
|
3335
|
732
|
58,512
|
61,027
|
6
|
1
|
Bhatt et al. 2012 [48]
|
USA
|
In-hospital
|
Parallel group trial
|
75
|
9,
|
1
|
47
|
60
|
484
|
789
|
10
|
8
|
Scott et al. 2013 [49]
|
USA
|
In-hospital
|
Randomised controlled trial
|
100
|
1,2,9
|
3
|
235
|
194
|
8419
|
9222
|
3
|
2
|
Meretoja et al. 2013 [50]
|
Australia
|
In-hospital
|
Uncontrolled before and after
|
79
|
2,7,9
|
3
|
47
|
82
|
324
|
468
|
15
|
18
|
McKinney et al. 2013 [51]
|
USA
|
Pre- and in-hospital
|
Parallel group trial
|
88
|
2,
|
1
|
31
|
17
|
114
|
115
|
27
|
15
|
Amorim et al. 2013 [52]
|
USA
|
In-hospital
|
Uncontrolled before and after
|
67
|
9,2
|
2
|
113
|
26
|
1669
|
919
|
7
|
3
|
Nolte et al. 2013 [53]
|
Germany
|
In-hospital
|
Uncontrolled before and after
|
79
|
2,
|
1
|
51
|
14
|
64
|
36
|
80
|
39
|
Prabhakaran et al. 2013 [47]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
79
|
2,
|
1
|
64
|
22
|
787
|
719
|
8
|
3
|
Schaik et al. 2014 [54]
|
Netherland
|
Pre- and in-hospital
|
Uncontrolled before and after
|
83
|
2,7,9
|
3
|
185
|
41
|
951
|
828
|
19
|
5
|
Fonarow et al. 2014 [55]
|
USA
|
In-hospital
|
Uncontrolled before and after
|
79
|
2,7,9
|
3
|
3552
|
1557
|
43,850
|
27,319
|
8
|
6
|
Ebinger et al. 2014 [56]
|
Germany
|
Pre-hospital
|
Randomised controlled trial
|
100
|
9,7
|
2
|
310
|
220
|
1070
|
1041
|
29
|
21
|
Minnerup et al. 2014 [57]
|
Germany
|
Pre- and in-hospital
|
Parallel group trial
|
63
|
9,
|
1
|
13,240
|
622
|
71,349
|
22,549
|
19
|
3
|
Camerlingo et al. 2014 [58]
|
Italy
|
Pre- and in-hospital
|
Uncontrolled before and after
|
83
|
1,5,9
|
3
|
23
|
8
|
401
|
376
|
6
|
2
|
Ruff et al. 2014 [59]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
75
|
2,7,9
|
3
|
142
|
116
|
925
|
1413
|
15
|
8
|
Hesselfeldt et al. 2014 [60]
|
Denmark
|
Pre-hospital
|
Parallel group trial
|
75
|
9,
|
1
|
22
|
87
|
65
|
265
|
34
|
33
|
Chen et al. 2014 [61]
|
Taiwan
|
In-hospital
|
Uncontrolled before and after
|
88
|
2,
|
1
|
216
|
91
|
2512
|
3500
|
9
|
3
|
Martinez-Sanchez et al. 2014 [62]
|
Spain
|
In-hospital
|
Uncontrolled before and after
|
83
|
9,2
|
2
|
18
|
12
|
225
|
259
|
8
|
5
|
Ragoschke-Schumm et al. 2015 [63]
|
UK
|
In-hospital
|
Parallel group trial
|
75
|
7,
|
1
|
66
|
49
|
174
|
81
|
38
|
60
|
Willeit et al. 2015 [64]
|
Austria
|
Pre- and in-hospital
|
Uncontrolled before and after
|
75
|
2,7
|
2
|
160
|
82
|
1238
|
1237
|
13
|
7
|
Kim et al. 2015 [65]
|
South Korea
|
In-hospital
|
Uncontrolled before and after
|
75
|
2,
|
1
|
202
|
44
|
341
|
132
|
59
|
33
|
Baldin et al. 2015 [66]
|
Australia
|
In-hospital
|
Uncontrolled before and after
|
79
|
9,2
|
2
|
16
|
10
|
62
|
58
|
26
|
17
|
Moran et al. 2016 [67]
|
Hawaii
|
In-hospital
|
Uncontrolled before and after
|
75
|
9, or 7
|
1
|
122
|
44
|
388
|
151
|
31
|
29
|
Busby et al. 2016 [68]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
75
|
2,
|
1
|
52
|
41
|
397
|
414
|
13
|
10
|
Choi et al. 2016 [69]
|
South Korea
|
In-hospital
|
Uncontrolled before and after
|
58
|
7,9
|
2
|
118
|
111
|
2078
|
2172
|
6
|
5
|
Nishijima et al. 2016 [70]
|
Japan
|
Pre-hospital
|
Uncontrolled before and after
|
71
|
1,
|
1
|
36
|
41
|
600
|
544
|
6
|
8
|
Kim et al. 2016 [71]
|
South Korea
|
Pre- and in-hospital
|
Parallel group trial
|
75
|
2,
|
1
|
215
|
59
|
306
|
136
|
70
|
43
|
Prabhakaran et al. 2016 [72]
|
USA
|
In-hospital
|
Parallel group trial
|
75
|
1,3,7,9
|
4
|
766
|
1626
|
10,314
|
15,261
|
7
|
11
|
Hubert et al. 2016 [73]
|
Finland
|
In-hospital
|
Parallel group trial
|
83
|
9,2
|
2
|
1779
|
912
|
11,589
|
3387
|
15
|
27
|
Itrat et al. 2016 [74]
|
USA
|
Pre-hospital
|
Parallel group trial
|
83
|
9,7
|
2
|
16
|
13
|
110
|
56
|
15
|
23
|
Denti et al. 2017 [75]
|
Italy
|
Pre-hospital
|
Randomised controlled trial
|
100
|
1,
|
1
|
145
|
156
|
649
|
503
|
22
|
31
|
Zaidi et al. 2017 [76]
|
USA
|
Pre- and in-hospital
|
Parallel group trial
|
79
|
2,5,7
|
3
|
28
|
18
|
109
|
142
|
26
|
13
|
Heikkila et al. 2019 [77]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
71
|
9,
|
1
|
51
|
124
|
355
|
1581
|
14
|
8
|
Hsiao et al. 2018 [78]
|
Taiwan
|
In-hospital
|
Parallel group trial
|
75
|
2,
|
1
|
40
|
18
|
254
|
118
|
16
|
15
|
Carvalho et al. 2018 [79]
|
Brazil
|
In-hospital
|
Uncontrolled before and after
|
75
|
5,7
|
2
|
28
|
13
|
154
|
61
|
18
|
21
|
Gurav et al. 2018 [80]
|
India
|
In-hospital
|
Uncontrolled before and after
|
75
|
2,
|
1
|
65
|
44
|
610
|
695
|
11
|
6
|
Tan et al. 2018 [81]
|
Sweden
|
Pre- and in-hospital
|
Uncontrolled before and after
|
75
|
2,7
|
2
|
281
|
129
|
826
|
416
|
34
|
31
|
Haesebaert et al. 2018 [82]
|
France
|
Pre- and in-hospital
|
Randomised controlled trial
|
100
|
1,5,7
|
3
|
140
|
114
|
363
|
328
|
39
|
35
|
Nguyen-Huynh et al. 2018 [83]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
88
|
2,7,9
|
3
|
557
|
310
|
3168
|
2375
|
18
|
13
|
Cone et al. 2018 [84]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
83
|
2,
|
1
|
94
|
181
|
219
|
316
|
43
|
57
|
Sadeghi-Hokmabadi et al. 2018 [85]
|
Iran
|
Pre- and in-hospital
|
Parallel group trial
|
79
|
2,
|
1
|
131
|
115
|
180
|
194
|
73
|
59
|
Meyer et al. 2008 [86]
|
USA
|
In-hospital
|
Randomised controlled trial
|
89
|
9,2
|
2
|
31
|
28
|
111
|
111
|
28
|
25
|
de Luca et al. 2009 [87]
|
Italy
|
In-hospital
|
Randomised controlled trial
|
100
|
5,9
|
2
|
15
|
2
|
434
|
328
|
3
|
1
|
Muller-Barna et al. 2014 [88]
|
Germany
|
In-hospital
|
Uncontrolled before and after
|
83
|
9,2
|
2
|
655
|
63
|
4409
|
2466
|
15
|
3
|
Vidale et al. 2016 [89]
|
Italy
|
Pre- and in-hospital
|
Parallel group trial
|
75
|
2,5,7
|
3
|
37
|
14
|
610
|
424
|
6
|
3
|
Nardetto et al. 2016 [90]
|
Italy
|
In-hospital
|
Parallel group trial
|
71
|
9,2
|
2
|
25
|
106
|
75
|
318
|
33
|
33
|
Hsieh et al. 2016 [91]
|
Taiwan
|
Pre- and in-hospital
|
Parallel group trial
|
79
|
2,
|
1
|
144
|
25
|
727
|
201
|
20
|
12
|
Jeon et al. 2017 [92]
|
South Korea
|
Pre- and in-hospital
|
Uncontrolled before and after
|
83
|
2,7
|
2
|
34
|
141
|
297
|
2012
|
11
|
7
|
Zhou et al. 2017 [93]
|
China
|
In-hospital
|
Parallel group trial
|
71
|
9,
|
1
|
231
|
88
|
712
|
689
|
32
|
13
|
Henry-Morrow et al. 2017 [94]
|
USA
|
Pre- and in-hospital
|
Uncontrolled before and after
|
50
|
1,
|
1
|
16
|
8
|
82
|
38
|
20
|
21
|