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Table 4 aAGREE-REX Scores For Specific Items, Overall Items (across the 11 Items), and Overall Assessments

From: Assessment of the quality of recommendations from 161 clinical practice guidelines using the Appraisal of Guidelines for Research and Evaluation–Recommendations Excellence (AGREE-REX) instrument shows there is room for improvement

Practice Guidelines (PG) Features Specific Items Means Overall Means Overall Assessments #
PGs
Evidence Clinical Relevance Patient/pop. Relevance Implement-ation Relevance Values Developers Values Users Values Patient/Pop Values Policy Alignment of Values Local Applicability Resources, Tools, Capacity Mean Overall Score % Score Mean Clinical Credibility Implement- ability
All Guidelines 5.15 (1.33) 5.47 (1.18) 4.87 (1.33) 4.46 (1.52) 4.61 (1.45) 4.28 (1.52) 3.85 (1.61) 3.44 (1.53) 3.42 (1.44) 3.56 (1.47) 3.49 (1.44) 4.23 (1.14) 54 (19) 4.78 (1.24) 4.19 (1.23) 161
Type of Organization
 Government Supported 5.61 (1.14) 5.95 (0.8) 5.57 (0.98) 5.48 (0.89) 5.26 (1.2) 4.97 (1.14) 4.83 (1.34) 4.56 (1.15) 4.11 (1.32) 4.52 (1.3) 4.41 (1.11) 5.02 (0.77) 67 (13) 5.28 (0.96) 4.85 (1.07) 46
 Professional Societies 4.98 (1.35) 5.24 (1.26) 4.57 (1.36) 4.04 (1.55) 4.30 (1.48) 3.98 (1.58) 3.41 (1.52) 2.99 (1.46) 3.1 (1.38) 3.17 (1.39) 3.06 (1.39) 3.89 (1.2) 48 (19) 4.56 (1.31) 3.89 (1.21) 109
 Other or Not Clear 4.83 (1.63) 6.17 (0.68) 5.00 (1.41) 4.42 (1.24) 5.17 (0.93) 4.5 (1.38) 4.42 (2.04) 3.00 (0.89) 3.75 (1.63) 3.33 (0.82) 4.25 (1.29) 4.44 (0.99) 57 (17) 4.83 (0.82) 4.50 (0) 6
p-value 0.021 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 0.004 <0.001  
Country
 US 5.06 (1.39) 5.33 (1.28) 4.68 (1.4) 4.17 (1.58) 4.51 (1.49) 4.12 (1.62) 3.61 (1.66) 3.08 (1.47) 3.31 (1.54) 3.26 (1.47) 3.22 (1.47) 4.03 (1.21) 51 (20) 4.62 (1.31) 3.98 (1.26) 89
 UK 5.26 (1.23) 5.74 (0.9) 5.22 (1.13) 5.04 (1.25) 4.86 (1.39) 4.76 (1.21) 4.23 (1.31) 4.16 (1.41) 3.66 (1.26) 4.18 (1.48) 4.12 (1.41) 4.66 (0.95) 61 (16) 5.06 (1.06) 4.51 (1.19) 46
 Canada 5.46 (1.21) 5.87 (0.64) 5.17 (1.19) 4.75 (1.5) 4.67 (1.51) 4.5 (1.58) 4.46 (2) 3.87 (1.61) 3.79 (1.48) 3.83 (1.27) 3.42 (1) 4.53 (1.08) 59 (18) 4.92 (1.12) 4.50 (1.1) 12
 International 5.18 (1.38) 5.18 (1.44) 4.64 (1.42) 4.18 (1.47) 4.39 (1.47) 3.54 (1.31) 3.64 (1.67) 2.96 (1.39) 2.96 (1.18) 3.18 (0.99) 3.25 (1.14) 3.91 (0.98) 49 (16) 4.75 (1.38) 4.21 (1.03) 14
p-value 0.7 0.1146 0.1192 0.011 0.5495 0.025 0.0932 <0.001 0.2609 0.0036 0.0056 0.0106 0.0106 0.2649 0.0851  
  1. aMean (SD); US United States, UK United Kingdom, Implement implementability, Patient/Pop Patients/population