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Table 6 Summary of impact of academic detailing visits on primary outcomes

From: The implementation of academic detailing and its effectiveness on appropriate prescribing of pain relief medication: a real-world cluster randomized trial in Belgian general practices

  ITT1 ITT2 PPR
  Step change [95% Wald CI]
Odds of being reimbursed for an analgesic or NSAID, in intervention compared to control group (PO1) 0.9973 [0.9860; 1.0088] 0.9929 [0.9780; 1.0081] 1.0218 [0.9982; 1.0459]
Average defined daily dose of paracetamol per patient reimbursed for paracetamol per month, in intervention compared to control group (PO2) − 0.3106 [− 0.8493; 0.2281] − 0.2442 [− 0.8677; 0.3793] − 0.2665 [− 0.8491; 0.3161]
Odds of being reimbursed for a recommended NSAID when reimbursed for any NSAID, in intervention compared to control group (PO3) 1.1887* [1.1004; 1.2841] 1.2158* [1.1276; 1.3109] 1.2158* [1.1276; 1.3109]
Odds of being reimbursed for an NSAID and a PPI when reimbursed for an NSAID, in intervention compared to control group (PO4) 1.0194 [0.9419; 1.1032] 1.0188 [0.9336; 1.1117] 1.0050 [0.9534; 1.0593]
  Change in trend [95% Wald CI]
Odds of being reimbursed for an analgesic or NSAID, in intervention compared to control group (PO1) 0.9882* [0.9790; 0.9975] 0.9896* [0.9806; 0.9987] 0.9990 [0.9945; 1.0035]
Average defined daily dose of paracetamol per patient reimbursed for paracetamol per month, in intervention compared to control group (PO2) 0.0389 [− 0.1446; 0.2224] 0.0937 [− 0.0686; 0.2560] 0.1400 [− 0.0513; 0.3313]
Odds of being reimbursed for a recommended NSAID when reimbursed for any NSAID, in intervention compared to control group (PO3) 0.9902 [0.9775; 1.0030] 0.9894 [0.9776; 1.0013] 0.9882 [0.9753; 1.0012]
Odds of being reimbursed for an NSAID and a PPI when reimbursed for an NSAID, in intervention compared to control group (PO4) 0.9940 [0.9765; 1.0118] 0.9944 [0.9762; 1.0129] 0.9968 [0.9770; 1.0170]
  1. Step change difference before and after the intervention; change in trend monthly change after the intervention; CI confidence interval; NSAID nonsteroidal anti-inflammatory drug; PPI proton pump inhibitor; ITT1 adjusted intention to treat analysis after dropping contaminated controls; ITT2 adjusted intention to treat analysis after dropping contaminated controls and fully contaminated cases; PPR per protocol analysis; *p value < 0.05