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Table 6 Summary of impact of academic detailing visits on primary outcomes

From: The implementation of academic detailing and its effectiveness on appropriate prescribing of pain relief medication: a real-world cluster randomized trial in Belgian general practices

 

ITT1

ITT2

PPR

 

Step change [95% Wald CI]

Odds of being reimbursed for an analgesic or NSAID, in intervention compared to control group (PO1)

0.9973 [0.9860; 1.0088]

0.9929 [0.9780; 1.0081]

1.0218 [0.9982; 1.0459]

Average defined daily dose of paracetamol per patient reimbursed for paracetamol per month, in intervention compared to control group (PO2)

− 0.3106 [− 0.8493; 0.2281]

− 0.2442 [− 0.8677; 0.3793]

− 0.2665 [− 0.8491; 0.3161]

Odds of being reimbursed for a recommended NSAID when reimbursed for any NSAID, in intervention compared to control group (PO3)

1.1887* [1.1004; 1.2841]

1.2158* [1.1276; 1.3109]

1.2158* [1.1276; 1.3109]

Odds of being reimbursed for an NSAID and a PPI when reimbursed for an NSAID, in intervention compared to control group (PO4)

1.0194 [0.9419; 1.1032]

1.0188 [0.9336; 1.1117]

1.0050 [0.9534; 1.0593]

 

Change in trend [95% Wald CI]

Odds of being reimbursed for an analgesic or NSAID, in intervention compared to control group (PO1)

0.9882* [0.9790; 0.9975]

0.9896* [0.9806; 0.9987]

0.9990 [0.9945; 1.0035]

Average defined daily dose of paracetamol per patient reimbursed for paracetamol per month, in intervention compared to control group (PO2)

0.0389 [− 0.1446; 0.2224]

0.0937 [− 0.0686; 0.2560]

0.1400 [− 0.0513; 0.3313]

Odds of being reimbursed for a recommended NSAID when reimbursed for any NSAID, in intervention compared to control group (PO3)

0.9902 [0.9775; 1.0030]

0.9894 [0.9776; 1.0013]

0.9882 [0.9753; 1.0012]

Odds of being reimbursed for an NSAID and a PPI when reimbursed for an NSAID, in intervention compared to control group (PO4)

0.9940 [0.9765; 1.0118]

0.9944 [0.9762; 1.0129]

0.9968 [0.9770; 1.0170]

  1. Step change difference before and after the intervention; change in trend monthly change after the intervention; CI confidence interval; NSAID nonsteroidal anti-inflammatory drug; PPI proton pump inhibitor; ITT1 adjusted intention to treat analysis after dropping contaminated controls; ITT2 adjusted intention to treat analysis after dropping contaminated controls and fully contaminated cases; PPR per protocol analysis; *p value < 0.05