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Table 3 Impact of academic detailing visits on secondary outcomes in an intention to treat analysis

From: The implementation of academic detailing and its effectiveness on appropriate prescribing of pain relief medication: a real-world cluster randomized trial in Belgian general practices

  Step change (β6) [99% Wald CI] Change in trend (β7) [99% Wald CI]
Average defined daily dose of analgesic and NSAIDs per patient reimbursed for an analgesic or NSAID per month, in intervention compared to control group (SO1) 0.0630 [− 0.2600; 0.3861] 0.0470 [− 0.0384; 0.1323]
Odds of being reimbursed for paracetamol, in intervention compared to control group (SO2) 1.0072 [0.9863; 1.0286] 0.9874 [0.9742; 1.0009]
Odds of being reimbursed for an NSAID, in intervention compared to control group (SO3) 1.0087 [0.9913; 1.0263] 0.9913 [0.9773; 1.0056]
Odds of being reimbursed for both an NSAID and a PPI when reimbursed for an NSAID for the first time in 3 months, in intervention compared to control group (SO4) 1.0450 [0.9520; 1.1472] 0.9907 [0.9434; 1.0404]
  1. Step change difference in step change between the intervention and control group immediately after the intervention; change in trend difference between the change in trend between the intervention and control group after the intervention; CI confidence interval; CI confidence interval; NSAID nonsteroidal anti-inflammatory drug; PPI proton pump inhibitor; *p value < 0.05; underlined, < 0.05 in all four analyses (ITT, ITT-V1, ITT-V2 and PPR)