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Table 1 Baseline characteristics and pregnancy outcomes of women with imminent preterm birth at participating Canadian Perinatal Network sites (2005–15) (N (%) women or median [IQR], unless otherwise stated)

From: MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP)—implementation of a national guideline in Canada

  Total
N = 7888
Pre-MAG-CP (2005–2011)
N = 4745
MAG-CP (2011–2015)
N = 3143
p values
Maternal demographics and past history
Maternal age at EDD (year) 31 [27, 35] 31 [27,35] 31 [27,35] 0.034
Pre-existing medical conditions
 Pre-existing hypertension 305 (3.9%) 178 (3.8%) 127 (4.0%) 0.600
 Diabetes mellitus 149 (1.9%) 79 (1.7%) 70 (2.2%) 0.090
 Venous thromboembolism 28 (0.4%) 25 (0.5%) 3 (0.1%) 0.001
Prior obstetric history
 Previous preterm birth 1383 (17.5%) 845 (17.8%) 538 (17.1%) 0.400
 Previous caesarean 930 (11.8%) 666 (14.0%) 264 (8.4%) < 0.001
Current pregnancy
Nulliparity 3909 (49.6%) 2303 (48.5%) 1606 (51.1%) 0.030
Multiple gestation 1507 (19.1%) 911 (19.2%) 596 (19.0%) 0.800
Smoking during pregnancy 1260 (16.0%) 833 (17.6%) 427 (13.6%) < 0.001
 Missing 52 33 19  
Gestational age at enrollment (week) 26.0 [24.4, 27.4] 26.1 [24.6, 27.6] 25.9 [24.4, 27.4] < 0.001
Indication for threatened preterm birth
 Preterm labour only 2324 (29.5%) 1375 (29.0%) 949 (30.2%) < 0.001
 PPROM only 1567 (19.9%) 960 (20.2%) 607 (19.9%)
 PTL and PPROM 1106 (14.0%) 591 (12.5%) 515 (16.4%)
 Antepartum haemorrhage only 1195 (15.1%) 764 (16.1%) 431 (13.7%)
 Other† 1696 (21.5%) 1055 (22.2%) 641 (20.4%)
Gestational age at delivery (week) 28.0 [26.0, 35.0] 28.0 [26.0, 35.0] 28.0 [26.0, 34.0] 0.036
 ≥ 37 weeks (and 0 days) 1404 (17.8%) 889 (18.7%) 515 (16.4%) 0.008
 34 weeks (and 0 days)–36 weeks (and 6 days) 821 (10.4%) 507 (10.7%) 314 (10.0%)
 29 weeks (and 0 days)–33 weeks (and 6 days) 1522 (19.3%) 926 (19.5%) 596 (19.0%)
 < 29 weeks (and 0 days) 4141 (52.5%) 2423 (51.1%) 1718 (54.7%)
Maternal outcomes
 Placental abruption after enrollment 635 (8.1%) 251 (5.3%) 384 (12.2%) < 0.001
 One/more serious maternal complications 2479 (31.4%) 1304 (27.5%) 1175 (37.4%) < 0.001
  Death 2 (0.03%) 2 (0.04%) 0 0.500
  Admission to ICU or HDU 98 (1.2%) 19 (0.4%) 79 (2.5%) < 0.001
  Chorioamnionitis 1789 (22.7%) 999 (21.1%) 790 (25.1%) < 0.001
  Cardiovascular 2 (0.03%) 1 (0.02%) 1 (0.03%) 0.999
  Respiratory 64 (0.8%) 38 (0.8%) 26 (0.8%) 0.999
  CNS 7 (0.09%) 5 (0.1%) 2 (0.06%) 0.700
  Renal 6 (0.08%) 4 (0.08%) 2 (0.06%) 0.999
  Hematological 72 (0.9%) 37 (0.8%) 17 (0.5%) 0.300
  Hepatic 11 (0.1%) 11 (0.2%) 0 0.004
  Infection 74 (0.9%) 50 (1.1%) 24 (0.8%) 0.200
Perinatal outcomes N = 9541 N = 5751 N = 3790  
 Stillbirth 291 (3.0%) 211 (3.7%) 80 (2.1%) < 0.001
 Neonatal death in the delivery room 164 (1.7%) 119 (2.1%) 45 (1.2%) 0.002
 Liveborn and admitted to NICU 7638 (80.1%) 4714 (82.0%) 2924 (77.2%) <0.001
  1. PPROM preterm premature rupture of membranes, CNS central nervous system, HDU high-dependency unit, ICU intensive care unit, IQR interquartile range, NICU neonatal intensive care unit
  2. †Other indications for threatened preterm birth in the absence of preterm labour, PPROM or antepartum haemorrhage included (not mutually exclusive) gestational hypertension (N = 227), intrauterine growth restriction (N = 238), short cervix (N = 476), prolapsed membranes (N = 249) or other non-CPN condition within the Maternal-Infant Care Network (N = 48) in the pre-MAG-CP era and gestational hypertension (N = 137), intrauterine growth restriction (N = 151), short cervix (N = 325) or prolapsed membranes (N = 157) in the MAG-CP era