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Table 3 Study variable measurement

From: Study protocol for “Study of Practices Enabling Implementation and Adaptation in the Safety Net (SPREAD-NET)”: a pragmatic trial comparing implementation strategies

RE-AIM components Measure Data source
Reach: rate of guideline-appropriate prescribing of ACE/ARBs, statins
[primary dependent variables]
(a) % clinic’s “indicated” patients with an active prescription (Rx issued in last year) for each indicated medication group
(b) % of patients indicated for statins, on the correct dosage
Monthly EHR data
Effectiveness: proportion of patient BP, LDL “under control” (targeted by statins, ACE/ARBs, respectively)
[secondary outcome]
% clinic’s “indicated” patients with:
(a) last systolic BP <135, last diastolic BP <80
(b) last LDL <100
Adoption: use of toolkit elements
- Site participation/uptake rates
- Staff participation/uptake rates overall/by staff role
[Process outcome]
(a) % indicated patient encounters where
 (i) appropriate prescription given
 (ii) statin dosage corrected
(b) rates of use of the roster tools
(c) rates of responses to “charting alerts:” how often the recommended change is made in the chart
(d) rates of responses to health maintenance alerts: data entered/recommended care provided
(e) % staff attending relevant trainings
(f) perceived value of patient/staff education materials
Monthly EHR data; qualitative data
Implementation: Compliance with, fidelity / adaptation to toolkit elements across and within sites How toolkit elements are used: e.g., use of staff training materials, patient education materials, patient panel management rosters, other reminder tools; any adaptations made to these materials Qualitative data
Maintenance: uptake of toolkit elements; primary, secondary outcome effects, over time All measures at 1, 2, 3 years post-implementation EHR, qualitative data