Leveraging practice-based research networks to accelerate implementation and diffusion of chronic kidney disease guidelines in primary care practices: a prospective cohort study

Table 1 Wave I modeling of intervention effect, adjusted for timing of recognition of CKD diagnosis in the medical record

Model effects	CKD guideline
Model effects	HbA1c measured	ACEI/ARB prescribed	Taking NSAIDS	Hgb measured		Vitamin D measured	Alb/Cr ratio measured
	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
Intervention effect (post- vs. pre-intervention)	NA	1.3 (1.1-1.6)	0.7 (0.4-1.0)	1.7 (1.1-2.6)	0.9 (0.7-1.3)	2.6 (1.7-3.8)	NA
p value		0.001	0.030	0.014	0.68	<0.0001	NA
CKD recognition:	NA						NA
Recognized pre-intervention vs. not recognized		0.9 (0.5-1.6)	0.9 (0.3-2.6)	2.9 (0.9-9.5)	1.1 (0.6-1.9)	0.9 (0.2-3.4)
Recognized post-intervention vs. not recognized		0.8 (0.4-1.6)	0.8 (0.2-2.6)	2.5 (0.7-8.6)	1.6 (0.9-3.1)	1.0 (0.3-3.9)
Recognized pre-intervention vs. recognized post-intervention		1.1 (0.7-1.7)	1.2 (0.5-2.7)	1.2 (0.6-2.2)	0.7 (0.4-1.1)	0.9 (0.5-1.7)
p value		0.84	0.92	0.30	0.18	0.95
Interaction of intervention with CKD recognition:
Post- vs. pre-intervention for CKD recognized pre-intervention	1.4 (1.0-1.9)						1.6 (1.1-2.1)
Post- vs. pre-intervention for CKD recognized post-intervention	1.1 (0.8-1.6)						1.2 (0.7-1.9)
Post- vs. pre-intervention for CKD not recognized	0.6 (0.3-1.0)						0.5 (0.3-0.9)
p value	0.037						0.004

NA not applicable (The main effects contributing to an interaction have different interpretations in the presence of the interaction).