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Table 1 Summary of results of CCDSS trials of primary preventive care

From: Computerized clinical decision support systems for primary preventive care: A decision-maker-researcher partnership systematic review of effects on process of care and patient outcomes

Study

Method Score

Indication

No. of centres/providers/patients

Process of care outcomes

CCDSS Effecta

Patient outcomes

CCDSS Effecta

Cancer screening

Sequist, 2009

[49]

9

Reminders to screen for colorectal cancer in primary care.

11 / 110* / 21,860

Individual tests performed: FOBT; Flexible sigmoidoscopy; Colonoscopy.

0

Pathologic findings: Colonic adenoma; Colorectal cancer.

0

Emery, 2007

[30]

10

Recommendations for assessment and management of familial cancer risk in primary care.

45* /.../ 219

Appropriate referrals to regional genetics clinic.

+

Cancer worry score; Risk perception score; Accuracy of patient risk perception; Knowledge about familial cancer.

0

Wilson, 2005

[57, 58]

6

Recommendations for referral and provision of information for breast cancer genetic risk in primary care.

86* / 243 / 242

Confidence in management of patients with family history of breast cancer concerns.

0

Perception of risk; Understanding of 'incorrect' breast cancer risk factors.

0

Burack, 2003

[24]

8

Reminders for mammography and pap smear tests in primary care.

3 / 20 / 2,471*

Primary care visit during study year; Mammogram completed during study year; Pap smear test completed during study year.

0

...

...

Burack, 1998

[23]

6

Reminders to perform pap smear screening in primary care.

3 / 20 / 5,801*

Patients with primary care visit; Patients with pap smear completed.

0

...

...

Burack, 1997

[22]

8

Reminders for mammography in primary care.

3 / 25 / 2,826*

Mammography completion rates.

+

...

...

Burack, 1996

[21]

8

Reminders for mammography screening in primary care.

2 / 20 / 2,368*

Primary care visit for women due for mammography; Mammography rates.

0

...

...

Burack, 1994

[20]

8

Reminders for mammography in primary care.

5 / 25 / 2,725*

Proportion of women with scheduled mammography appointments; Proportion of women having mammography.

+

...

...

McPhee, 1991

[40]

7

Reminders for cancer screening and preventive counselling in primary care.

.../ 40* /...

Compliance with American Cancer Society and/or National Cancer Institute recommendations.

+

...

...

McPhee, 1989

[39]

7

Reminders for cancer screening and preventive counselling in primary care.

1 / 62* / 1,936

Compliance with recommendations for FOBT, rectal exam, sigmoidoscopy, pap smear test, pelvic exam, breast exam, and mammography.

+

...

...

Multiple preventive care activities

Harari, 2008

[34]

7

Recommendations for primary preventative care and screening for functionally independent elderly patients in primary care.

4 / 26 / 2,503*

BP check, FOBT (<80 years of age), influenza vaccination, dental check, vision check-up, or hearing check-up in previous year; Cholesterol measurement in previous five years (<75 years of age); Blood glucose measurement in previous three years; Pneumococcal vaccination (ever); Mammography in previous two years (<70 years of age).

0

Moderate or strenuous physical activity; Consumption of high fat food items; Consumption of fruit/fibre items; No current tobacco use; No or moderate alcohol use; Driving with use of seat belt.

0

Apkon, 2005

[16]

5

Screening, preventive care, and recommendations for management of acute or chronic conditions for ambulatory care patients in military facilities.

3 / 12 / 1,902*

Screening/prevention healthcare opportunities fulfilled; Acute/chronic healthcare opportunities (lipid abnormalities); Patient satisfaction.

0

Adverse events.

0

Dexter, 2001

[29]

10

Reminders for preventive therapies in hospital inpatients.

...* / 202 / 3,416

Proportion of hospitalizations with an order for therapy (all patients and only eligible patients).

+

...

...

Demakis, 2000

[28]

7

Reminders for screening, monitoring, and counselling in accordance with predefined standards of care in ambulatory care.

12* / 275 / 12,989

Per-patient and per-visit compliance with standards of care related to hypertension (weight, exercise, sodium), nutrition counselling for diabetes, and pneumococcal vaccination for elderly or high-risk patients.

+

...

...

Overhage, 1996

[42]

10

Reminders to comply with 22 US Preventive Services Task Force preventive care measures for hospital inpatients.

1* / 78 / 1,622

Compliance with preventive care guidelines; Attitude towards providing preventive care to hospitalised patients.

0

...

...

Frame, 1994

[33]

6

Reminders for cancer screening, CV disease preventive screening, identification of at-risk behavior, patient education, and vaccination in primary care.

5 / 12 / 1,324*

Change in provider compliance with 11 health maintenance procedures over two years.

+

...

...

Turner, 1994

[53]

5

Reminders for cancer screening and influenza vaccination in primary care.

44* / 44 / 740

Performance of health maintenance activities including influenza vaccinations, FOBTs, pap smears, breast exams, and mammography.

0

...

...

Ornstein, 1991

[41]

7

Reminders for preventive care services for adults in family medicine clinic.

1* / 49 / 7,397

Proportion of patients who received each of five preventive services.

+ for combined reminders

0 for physician or patient reminders

...

...

Rosser, 1991

[46]

6

Reminders for cancer screening, BP measurement, assessment of smoking status, and vaccination in outpatients.

1 /.../ 5,883*

Percentage of patients for whom the recommended procedures were performed.

+

...

...

Tierney, 1986

[52]

6

Reminders of preventive care protocols for outpatients.

1* / 135 / 6,045

Physician compliance with preventive care protocols for fecal blood testing, pneumococcal vaccination, antacids, tuberculosis skin testing, calcium supplements, cervical cytology, mammography, and

saclicylates.

+

...

...

Screening and management of CV risk factors

Bertoni, 2009

[18, 19]

9

Recommendations for screening and treatment of dyslipidaemia in primary care.

59* / ... / 3,821

Patients with appropriate lipid management at follow-up.

+

...

...

Van Wyk, 2008

[56]

10

On-demand and automatic alerts to screen and treat dyslipidaemia in primary care.

38* / 80 / 92,054

Screening of appropriate patients.

Auto, +

On-demand, 0

...

...

Unrod, 2007

[54, 55]

8

Recommendations to increase smoking cessation counselling and quit rates in primary care.

... / 70* / 465

Physician implementation of guideline including assessment and discussion of smoking behavior, support interventions for quitting, and referral to quit-smoking programs.

+

Seven-day point-prevalence for abstinence.

0

Cobos, 2005

[27]

10

Recommendations for treatment, monitoring and follow-up for patients with dyslipidaemia in primary care.

42* /.../ 2,221

Treatment with lipid-lowering drugs in patients without coronary heart disease.

+

Successful management of patients without coronary heart disease.

0

Kenealy, 2005

[35]

10

Reminders for screening for diabetes in outpatients.

66* / 107 / 5,628

Percentage of eligible patients visiting a practitioner and screened for diabetes.

+

...

...

Filippi, 2003

[31]

7

Reminders to prescribe acetylsalicylic acid or other antiplatelet agents to diabetic primary care patients.

... / 300* / 15,343

Antiplatelet drug prescription for patients with cardiac risk factors but without CVD.

+

...

...

Lowensteyn, 1998

[38]

6

Calculation of coronary risk factor profile for outpatients and identification of high-risk patients in primary care.

24* / 253 / 958

Ratio for high-risk/low-risk patients returning for reassessment at three months.

+

Total cholesterol; Total / high-density lipoprotein cholesterol ratio; Body mass index; High-density lipoprotein cholesterol; Low-density lipoprotein cholesterol; Systolic BP; Diastolic BP; Proportion of smokers; eight-year coronary risk; CV age.

+

Rogers, 1984

[43–45]

4

Detection of deficiencies in care and recommendations for the management of hypertension, obesity and renal disease in outpatients.

1 / ... / 484*

Number of diets given or reviewed for obesity patients; Perceived quality of communication.

+

Perceived health status.

+

Barnett, 1983

[17]

4

Reminders to follow-up patients with newly-identified elevated BP in an acute care setting.

1 / ... / 115*

Patient follow-up attempted or achieved; Repeat BP measurement recorded.

+

Degree of BP control.

+

Screening and management of mental health-related conditions

Ahmad, 2009

[15]

8

Computer-assisted screening for intimate partner violence in primary care.

1 / 11 / 314*

Opportunity to discuss possibility of risk for intimate partner violence; Detection of intimate partner violence when patient identified risk as being present and recent.

+

...

...

Thomas, 2004

[51]

7

Identification and recommendations for management of anxiety and depression in outpatients.

5 / ... / 762*

Patient satisfaction with general practitioner.

0

General Health Questionnaire score.

+

Schriger, 2001

[48]

8

Provided computerized psychiatric interview and recommendations for patient diagnosis in the emergency department.

1 / 104 / 259*

Proportion of patients assigned a psychiatric diagnosis by CCDSS who received a psychiatric diagnosis, consultation or referral in the emergency department.

0

...

...

Cannon, 2000

[26]

4

Reminders for screening and diagnosis of mood disorder in an outpatient mental health clinic.

1 / 4 / 78*

Proportion of patients screened for mood disorder; Proportion of major depressive disorder cases with fully documented diagnostic criteria (Diagnostic and Statistical Manual for Mental Disorders, 4 th edition).

+

...

...

Lewis, 1996

[37]

6

Provided assessment for common mental disorders in primary care.

1 / 8 / 681*

Consultations; Referrals to other professionals; Drug prescriptions.

0

Difference in General Health Questionnaire score.

0

Rubenstein, 1995

[47]

7

Computer-generated feedback designed to identify and suggest management for functional deficits in primary care.

2* / 73 / 557

Clinical problems in medical records; Patients identified as having physical, psychological or social function impairments; Functional status interventions overall and for patients with functional status problems; Physician attitudes toward managing functional status.

...

Patient functional status.

0

Vaccinations

Fiks, 2009

[1]

8

Alerts for influenza vaccination for children and adolescents with asthma in primary care.

20* / ... / 11,919

Captured opportunities for vaccination and up-to-date vaccination rates (adjusted analysis).

0

...

...

Flanagan, 1999

[32]

3

Online reminders for tetanus, hepatitis, pneumococcal, measles, and influenza vaccinations for adults in primary care.

... / 233* / 817

Correct vaccine decisions.

0

...

...

Chambers, 1991

[25]

6

Reminders for influenza vaccination in primary care.

1 / 30* / 686

Influenza vaccines given.

+ for always reminders

0 for sometimes reminders

...

...

Other preventive care activities

Sundaram, 2009

[50]

7

Reminders for risk assessment and screening for HIV in primary care.

5 / 32* / 26,042

Change in HIV testing rates.

0

...

...

Lafata, 2007

[36]

9

Reminders for osteoporosis screening for elderly, female outpatients in primary care.

15* / 123 / 10,354

Bone mineral density testing.

+

...

...

Zanetti, 2003

[59]

8

Alert to redose prophylactic antibiotics during prolonged cardiac surgery.

1 / ... / 447*

Intraoperative redose of antibiotics.

+

Surgical-site infection.

0

  1. Abbreviations: BP, blood pressure; CCDSS, computerized clinical decision support system; CV(D), cardiovascular disease; FOBT, fecal occult blood test; HIV, human immunodeficiency virus.
  2. *Unit of allocation.
  3. aOutcomes are evaluated for effect as positive (+) or negative (-) for CCDSS, or no effect (0), based on the following hierarchy. An effect is defined as ≥50% of relevant outcomes showing a statistically significant difference (2p<0.05):
  4. 1. If a single primary outcome is reported, in which all components are applicable, this is the only outcome evaluated.
  5. 2. If >1 primary outcome is reported, the ≥50% rule applies and only the primary outcomes are evaluated.
  6. 3. If no primary outcomes are reported (or only some of the primary outcome components are relevant) but overall analyses are provided, the overall analyses are evaluated as primary outcomes. Subgroup analyses are not considered.
  7. 4. If no primary outcomes or overall analyses are reported, or only some components of the primary outcome are relevant for the application, any reported prespecified outcomes are evaluated.
  8. 5. If no clearly prespecified outcomes are reported, any available outcomes are considered.
  9. 6. If statistical comparisons are not reported, 'effect' is designated as not evaluated (...).