Multiple uncontrolled conditions and blood pressure medication intensification: an observational study

Table 2 Bivariate associations with blood pressure medication intensification among 387 patients presenting with uncontrolled blood pressure

	BP medication intensification rates		Odds ratio	95% Confidence Interval
Patient Factors	# intensified/total #	%		lower limit	upper limit	P
Age (years)
< 55	28/92	30.4	0.61	0.35	1.06	0.29
55 to 64	57/136	41.9	Referent
≥ 65	50/159	31.5	0.64	0.39	1.03	0.36
Sex
Male	133/373	35.7	Referent
Female	2/14	14.3	0.3	0.07	1.36	0.12
Systolic BP (mmHg) (mean)
< 140	21/122	17.2	Referent
140 to 159	72/196	36.7	2.79	1.61	4.85	0.93
≥ 160	42/69	60.9	7.48	3.81	14.68	< 0.001
Systolic BP < 10 mmHg above goal
Yes	39/203	19.2	Referent
No	96/184	52.2	4.59	2.92	7.22	< 0.01
Number of medications*
0	39/122	31.5	0.68	0.35	1.33	0.35
1 to 2	40/114	29.5	Referent
3 to 4	34/97	25.1	0.79	0.40	1.53	0.89
5+	22/54	13.9	0.79	0.40	1.56	0.89
Diabetes
Present-Uncontrolled	36/98	36.7	1.37	0.76	2.49	0.52
Present-Controlled**	30/101	29.7	Referent
Not present	69/188	36.7	1.37	0.82	2.30	0.46
Hyperlipidemia
Present-Uncontrolled	33/103	32.0	1.46	0.87	2.45	0.11
Present-Controlled**	65/196	33.2	Referent
Not present	37/88	42.1	0.95	0.57	1.58	0.33
Clinical scenario: Uncontrolled BP AND
No diagnosed diabetes or HLD†	30/76	39.5	1.53	0.86	2.71	0.72
Controlled diabetes and/or HLD	47/157	29.9	Referent
Either uncontrolled diabetes or HLD	43/122	35.3	1.27	0.77	2.11	0.56
Both uncontrolled diabetes and HLD	15/32	46.9	2.07	0.95	4.48	0.18

*Medications for hypertension, diabetes, and/or hyperlipidemia prescribed in the 90 days prior to the index visit; **Includes missing laboratory data: 23 hemoglobin A1c levels and 41 lipid levels; †HLD = Hyperlipidemia

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