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  • Meeting abstract
  • Open Access

Expanding D&I science capacity and activity within NIH Clinical and Translational Science Award (CTSA) Programs: guidance and successful models from national leaders

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Implementation Science201510 (Suppl 1) :A38

  • Published:


  • Effective Dissemination
  • Implementation Policy
  • Public Health Intervention
  • Implementation Research
  • Implementation Science

The NIH CTSA program (Clinical and Translational Science Awards) supports over 60 research centers working to accelerate scientific discovery, development and implementation to improve health. The CTSA initiative was launched in 2006 to accelerate progress along the research pipeline by overcoming the "translational roadblocks" identified by the Institute of Medicine's Clinical Research Roundtable (CRR)-and discussed in numerous additional reports published in the U.S. and internationally. Although the CRR and its international counterparts identified two broad categories of roadblocks, the first impeding the translation of basic science discoveries into effective clinical and public health interventions and the second impeding appropriate implementation-in-practice and societal benefits of these interventions, to date most CTSA activity has focused largely on the first translational roadblock. The presentations included in this panel represent national leaders in the establishment of effective programs to support and expand CTSA activity related to the second translational roadblock, barriers to effective dissemination, implementation and achievement of population health benefit of NIH-funded research. The presentations describe the components, activities and impacts of CTSA-based D&I science programs established at the University of California at San Francisco, University of North Carolina at Chapel Hill, and Washington University at St. Louis. The panel will also describe the ongoing development of a new program at the University of California at Los Angeles (guided by the three programs featured in the panel) and will feature comments by key national research leaders addressing the value and role of these national leaders in stimulating and guiding similar efforts across other CTSAs and similar research institutions.

Implications for D&I science

The NIH CTSA program represents a significant investment of research resources in the nation's leading universities and health research institutes. The mission of the program cannot be achieved without a significant increase in efforts to implement CTSA-generated findings and innovations, however, and, hence, without a robust program of implementation research to guide implementation policy and practice. This panel will contribute to ongoing efforts to stimulate and support expanded implementation science interest and activity.

Authors’ Affiliations

Center for Implementation Practice and Research Support, US Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 91343, USA
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA
Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Brown School of Social Work, Washington University in St Louis, St Louis, MO 63130, USA
Department of Epidemiology & Biostatistics and Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA
Center for Vulnerable Populations, San Francisco General Hospital, San Francisco, CA 94110, USA


© Mittman et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.