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Table 1 PICO for the review

From: The effectiveness of interventions to disseminate the results of non-commercial randomised clinical trials to healthcare professionals: a systematic review

Population: professional audiences

The population for our review was health professionals, policymakers, guideline developers and healthcare commissioners, not restricted by age, sex, location or other demographic factors

Intervention: interventions to communicate or disseminate the results of clinical studies

We were interested in interventions aiming to disseminate or communicate the overall results of clinical studies to the population described above. We were primarily interested in interventions sharing the results of phase III non-commercial clinical trials but also explored the literature on disseminating the results of other clinical research study designs that are likely to generate evidence with direct implications for policy and practice (for example, systematic reviews and cohort studies). We did not pre-specify which interventions (dissemination methods) we were interested in, as we wished to be inclusive of all strategies that had been examined in the literature

Comparator/study design: no comparator specified

We did not specify a particular comparator or study design

Outcomes: changes in policy and clinical practice

We explored a range of outcomes, covering the out-takes, outcomes and impact dimensions of the International Association for the Measurement and Evaluation of Communication Framework [4]. Our co-primary outcomes were changes in the recommendations made in clinical policy documents and clinical guidelines published by professional bodies or government agencies and changes in clinical practice