Question 1, Profile 1: Should skin prick tests be used for the diagnosis of IgE-mediated CMA in patients suspected of CMA? Cut-off ≥3 mm | All populations | ||||||||||
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Outcome | No. of studies | Study design | Factors that may decrease quality of evidence | Final quality | Effect per 10001 | Importance | ||||
Limitations | Indirectness | Inconsistency | Imprecision | Reporting bias | ||||||
True positives (patients with CMA) | 23 studies (2302 patients) | Consecutive or non-consecutive series | Serious2 | None | Serious3 | None | Unlikely | ⊕⊕OO low | Prev 80%: 536 Prev 40%: 268 Prev 10%: 67 | CRITICAL |
True negatives (patients without CMA) | 23 studies (2302 patients) | Consecutive or non-consecutive series | Serious2 | None | Serious3 | None | Unlikely | ⊕⊕OO low | Prev 80%: 108 Prev 40%: 324 Prev 10%: 486 | CRITICAL |
False positives (patients incorrectly classified as having CMA) | 23 studies (2302 patients) | Consecutive or non-consecutive series | Serious2 | Serious4 | Serious3 | None | Unlikely | ⊕OOO very low | Prev 80%: 92 Prev 40%: 276 Prev 10%: 414 | CRITICAL |
False negatives (patients incorrectly classified as not having CMA) | 23 studies (2302 patients) | Consecutive or non-consecutive series | Serious2 | None | Serious3 | None | Unlikely | ⊕⊕OO low | Prev 80%: 264 Prev 40%: 132 Prev 10%: 33 | CRITICAL |
Inconclusive5 | 1 study (310 patients) | Non-consecutive series | - | - | - | - | - | - | - | IMPORTANT |
Complications | Not reported | - | - | - | - | - | - | - | - | NOT IMPORTANT |
Cost | Not reported | - | - | - | - | - | - | - | - | NOT IMPORTANT |