Study protocol for a factorial-randomized controlled trial evaluating the implementation, costs, effectiveness, and sustainment of digital therapeutics for substance use disorder in primary care (DIGITS Trial)

Table 3 General procedures for using reSET and reSET-O in primary care

Initiate a patient onto reSET or reSET-O	Support for use of reSET or reSET-O
• Identify patients who may benefit from reSET or reSET-O¹ (from warm hand-offs, referrals, scheduled appointments, population management registries) • Offer via shared decision making • Enter an electronic order for the treatment to facilitate a prescription • Provide instructions to the patient and an enrollment code for app activation • Follow-up with patients as indicated during the 12-week prescription	• Encourage completion of 4 modules per week • Monitor use of the app with the clinician dashboard • Identify barriers to engagement • Review content learned • Encourage skill practice • Consolidate what patients learn and discuss next steps

¹Eligibility criteria for reSET and reSET-O can be briefly summarized as: aged 18 years or older, has a diagnosis of substance use disorder, has access to a tablet or smartphone with intervention access, primary language is English, and able to review the Terms of Service and Privacy Policy. reSET is indicated for patients with substance use disorder except sole alcohol use disorder or primary opioid use disorder. reSET-O is indicated for patients with opioid use disorder who are taking buprenorphine. The exact eligibility criteria are available on the Pear Therapeutics website.

ISSN: 1748-5908