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Table 5 Subgroup analyses

From: Implementation strategies to improve statin utilization in individuals with hypercholesterolemia: a systematic review and meta-analysis

Study subgroup (number of studies)

Subgroup

Comparison group

P value for interaction

Odds ratio, (95% CI)

 Statin prescribing (11)

  More than 2 implementation strategies (6)

2.19 (1.32–3.63)

2.40 (1.43–4.06)

0.80

  Study published in 2013 or later (5)

1.97 (1.29–3.01)

2.84 (1.41–5.74)

0.36

  Conducted in the United States (2)

4.00 (1.03–15.50)

1.95 (1.33–2.84)

0.32

 LDL-C (14)

  More than 2 implementation strategies (4)

1.53 (1.23–1.90)

1.20 (0.97–1.48)

0.12

  Study published 2013 or later (5)

1.62 (1.19–2.19)

1.13 (0.95–1.35)

0.05

  Conducted in the United States (5)

1.48 (1.12–1.95)

1.29 (1.03–1.61)

0.35

Standardized mean difference, (95% CI)

 LDL-C (17)

  More than 2 implementation strategies (6)

− 0.38 (− 0.67; − 0.09)

− 0.07 (− 0.15; − 0.01)

0.05

  Study published in 2013 or later (8)

− 0.12 (− 0.21; v0.02)

− 0.23 (− 0.39; − 0.07)

0.24

  Conducted in the United States (6)

− 0.20 (− 0.36; − 0.04)

− 0.17 (− 0.31; − 0.03)

0.79

  1. Statin adherence was excluded because there were not enough studies to make a comparison