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Table 1 Study characteristics, taxonomy strategies used in interventions, and summary of study outcomes

From: Effectiveness of guideline dissemination and implementation strategies on health care professionals’ behaviour and patient outcomes in the cancer care context: a systematic review

Study (country)

Study design

Participants

Setting

CPGb

Mazza taxonomy strategies

Outcomesc

HCP

Patients

Experimental conditiona

Comparator condition

Primary (HCP level)

Secondary (patient-level)

Aspy et al. [28] (USA)

RCT

Primary care providers

Breast

Outpatient

Screening

1.5 Educate individual

1.12 Feedback about patients

3.1.1Additional human resources

No intervention

N/A

+ Screening rate

Ayanian et al. [29] (USA)

RCT

Primary care physicians

Colorectal

Outpatient

Inpatient

Screening

1.9 Provide reminders

No intervention

N/A

+ Test completion

+ Detection of cancer

Bertsche et al. [30] (Germany)

QE

Physicians, nurses, pharmacists

Tumour pain

Inpatient

Appropriate symptom management

1.2 Distribute guideline

1.5 Educate individual

1.12 Feedback about patients

3.3.4 Change in technology

No intervention

Antecedent (acceptance of recommendations; N.R.)

+ Behaviour (deviations from guideline)

+ Symptom management

Burack et al. [31] (USA)

RCT

Primary care physicians, internal medicine, gynaecology

Cervical

Outpatient

Screening

1.9 Provide reminders

Patient-directed strategy

1.9 Provide reminders

No intervention

N/A

Ø Test completion

Carney et al. [32] (USA)

RCT

Radiologists

Breast

Outpatient

Screening -

1.5 Educate individual

1.11 Feedback guideline compliance

1.12 Feedback about patients

1.15 Other—goal setting

No intervention

Ø Behaviour (recall rate)

N/A

Cohn et al. [33] (USA)

QE

Obstetrician-gynaecologists, physicians

Cervical

Outpatient

Screening

1.2 Distribute guideline

1.3 Advertise guideline

1.5 Educate individual

1.5 Educate individual

1.9 Provide reminders

Patient-directed strategy

1.2 Distribute guideline

1.5 Educate individual

1.5 Educate individual

1.9 Provide reminders

No intervention

+ Antecedent (knowledge of guideline)

+ Antecedent (exposure to guidelines)

+ Antecedent (patient history)

N/A

Coleman et al. [34] (USA)

QE

Nurses, physicians, mammography technicians

Breast

Outpatient

Screening

1.5 Educate individual

1.9 Provide reminders

1.12 Feedback about patients

Patient-mediated strategy

No intervention

Ø Antecedent (knowledge and attitude)

Antecedent (skill; N.R.)

Ø Screening rate

Du Pen et al. [35] (USA)

RCT

Oncology nurses, oncologists

Cancer pain

Outpatient

Appropriate symptom management

1.2 Distribute guideline

1.6 Educate group

1.7 Recruit opinion leader

1.15 Other—algorithm

1.15 Other—algorithm

+ Behaviour (total provider adherence)

+ Symptom management (pain outcomes)

Du Pen et al. [36] (USA)

RCT

Oncology nurses, oncologists

Cancer pain (breast, lung, colorectal, prostate, pancreatic, ovarian, etc.)

Outpatient

Appropriate symptom management

1.2 Distribute guideline

1.15 Other—algorithm

No intervention

Behaviour (total provider adherence; N.R.)

+ Symptom management

Ø Quality of life

Emery et al. [37]

(UK)

RCT

General practitioners, nurses

Breast, colorectal

Outpatient

Screening

1.5 Educate individual

1.6 Educate group

1.7 Recruit opinion leader

3.3.4 Change in technology

1.2 Distribute guideline

1.6 Educate groups

Antecedent (attitude; N.R.)

Antecedent (confidence; N.R.)

Antecedent (barriers; N.R.)

+ Behaviour (screening referral)

N/A

Ferreira et al. [38] (USA)

RCT

Physicians, nurses

Colorectal

Outpatient

Screening

1.6 Educate group

1.11 Feedback guideline compliance

1.12 Feedback about patients

1.14 Feedback from health care professionals

Patient-mediated strategy

No intervention

+ Behaviour (screening recommendations)

+ Screening rate

Ganz et al. [39] (USA)

RCT

Primary care providers, nurses, administrative staff

Colorectal

Outpatient

Screening

1.1 Identify barriers

1.2 Distribute guideline

1.6 Educate group

1.7 Recruit opinion leader

1.9 Provide reminders

1.14 Feedback from health care professionals

Patient-directed strategy

No intervention

Antecedent (uptake of intervention; N.R.)

Ø Screening rate

Gorin et al. [40] (USA)

RCT

Primary care physicians

Breast

Outpatient

Screening

1.5 Educate individual

1.6 Educate group

1.9 Provide reminders

Patient-directed strategy

No intervention

+ Antecedent (knowledge)

+ Antecedent (perception of barriers)

+ Behaviour (screening recommendation)

+ Screening rate

Hillman et al. [41] (USA)

RCT

Primary care providers

Breast,

cervical, colorectal

Outpatient

Screening

1.12 Feedback about patients

2.1.2 Incentive to institution

No intervention

Ø Behaviour (screening recommendations)

N/A

Hountz et al. [42] (USA)

QE

Nurses

Colorectal

Outpatient

Screening

1.6 Educate group

1.11 Feedback guideline compliance

3.3.4 Change in technology

Patient-directed strategy

No intervention

+ Behaviour (screenings ordered)

+ Test completion

Kerfoot et al. [43] (USA)

RCT

Primary care physicians, nurses, physician assistants

Prostate

Outpatient

Screening -

1.11 Feedback guideline compliance

No intervention

Antecedent (knowledge; N.R)

+ Behaviour (antigen screening deviations)

N/A

Lane et al. [44] (USA)

QE

Primary care physicians

Breast

Outpatient

Screening

1.5 Educate individual

1.13 Feedback from patients

No intervention

Ø Behaviour (screening referral)

N/A

Lane et al. [45] (USA)

RCT

Physicians, nurses, physician assistants

Colorectal

Outpatient

Screening

1.1 Identify barriers

1.6 Educate group

1.8 Achieve consensus

3.1.2 Reallocated roles

3.1.3 Implementation team

No intervention

+ Behaviour (screening referral)

N/A

Ling et al. [46] (USA)

RCT

Family practice, internal medicine physicians

Colorectal

Outpatient

Screening

1.1 Identify barriers

1.6 Educate group

1.10 Provide alerts

3.1.6 Other—development of protocols

3.1.6 Other—changing intervention to facilitate ease of use

Patient-directed strategy

1.10 Provide alerts

1.6 Educate groups

3.1.6 Other—development of protocols

Patient-directed strategy

N/A

+ Test completion

Manfredi et al. [47] (USA)

RCT

Primary care physicians

Breast, cervical, colorectal

Outpatient

Screening

1.3 Advertise guideline

1.4 Present guideline

1.6 Educate group

1.10 Provide alerts

1.11 Feedback guideline compliance

3.3.5 Change in quality assurance

1.3 Advertise guideline

N/A

+ Test completion

McDonald et al. [48] (USA)

RCT

Nurses

Cancer pain

Outpatient

Appropriate assessment/instruction practices

1.2 Distribute guideline

1.3 Advertise guideline

1.9 Provide reminders

3.1.1 Additional human resources

1.3 Advertise guideline

1.9 Provide reminders

No intervention

Ø Behaviour (pain assessment)

Ø Symptom management and quality of life

Myers et al. [26, 27] (USA)

RCT

Primary care physicians

Colorectal

Outpatient

Screening

1.1 Identify barriers

1.6 Educate group

1.9 Provide reminders

1.11 Feedback guideline compliance

1.12 Feedback about patients

1.9 Provide reminders

+ Behaviour (screening)

+ Screening rate

Ornstein et al. [49] (USA)

RCT

Primary care physicians, nurses

Colorectal

Outpatient

Screening

1.4 Present guideline

1.11 Feedback guideline compliance

1.12 Feedback about patients

1.15 Other—education on ‘best’ implementation strategies

3.1.2 Reallocated roles

1.4 Present guideline materials

3.12 Reallocated roles

+ Behaviour (method of screening)

+ Test completion

Patil et al. [50] (India)

QE

Physicians

N.R.

Outpatient

Appropriate symptom management

1.3 Advertise guideline

1.11 Feedback guideline compliance

3.3.5 Change in quality assurance

4.1 Change in legislation

No intervention

+ Behaviour (physician adherence; prescription overuse)

N/A

Phillips et al. [51] (Australia)

QE

Nurses

Lung, breast, gynaecological, colorectal, other

Inpatient

Appropriate symptom management

1.5 Educate individual

1.11 Feedback guideline compliance

No intervention

+ Antecedent (knowledge)

+ Antecedent (confidence)

+ Behaviour (pain assessment and documentation)

N/A

Raj et al. [52] (Norway)

QE

Oncologists

Breast, prostate, colorectal, lymphoma, lung, testicular, anal, upper gastrointestinal, other

Outpatient

Pain management

1.12 Feedback about patients

3.3.4 Change in technology

No intervention

Ø Behaviour (prescription)

Ø Symptom management (pain outcomes)

Rat et al. [53] (France)

RCT

General practitioners

Colorectal

Outpatient

Screening

1.12 Feedback about patients

1.11 Feedback guideline compliance

No intervention

+ Behaviour (screening)

N/A

Ray-Coquard et al. [54] (France)

QE

Physicians

Breast, colon

Outpatient

Appropriate treatment sequence (screening, procedures, continuity of care)

1.2 Distribute guideline

1.6 Educate group

1.7 Recruit opinion leader

1.8 Achieve consensus

No intervention

Behaviour (compliance with CPG; Ø breast; + colon)

N/A

Ray-Coquard et al. [55] (France)

QE

Physicians

Breast, colon

Outpatient

Appropriate treatment sequence (screening, procedures, continuity of care)

1.2 Distribute guideline

1.6 Educate group

1.8 Achieve consensus

No intervention

+ Behaviour (compliance with CPG)

N/A

Roila et al. [56] (Italy)

RCT

Oncologist

Breast, lung, ovary, colorectal, other

Inpatient

Appropriate symptom management

1.2 Distribute guideline

1.6 Educate group

1.11 Feedback guideline compliance

1.2 Distribute guideline

1.11 Feedback guideline compliance

1.2 Distribute guideline

+ Behaviour (prescription)

N/A

Sequist et al. [57] (USA)

RCT

Primary care physicians

Colorectal

Outpatient

Screening

1.9 Provide reminders

Patient-mediated strategy

1.9 Provide reminders

Patient-mediated strategy

No intervention

Antecedent (attitude; N.R.)

Ø Screening rate

+ Detection of cancer

Walsh et al. [58] (USA)

RCT

Primary care physicians

Colorectal

Outpatient

Screening

1.1 Identify barriers

1.5 Educate individual

1.6 Educate group

1.7 Recruit opinion leader

Patient-mediated strategy

1.6 Educate groups

N/A

Ø Screening rate

Wright et al. [67] (Canada)

RCT

Physicians

Colon

Outpatient

Accuracy of diagnosis

1.5 Educate individual

1.6 Educate group

1.7 Recruit opinion leader

1.9 Provide reminders

1.6 Educate groups

Ø Behaviour (staging)

N/A

  1. CPG clinical practice guideline, HCP health care professional, N/A not measured in study so not applicable, N.R. measured in study but not reported, QE quasi-experimental, RCT randomized controlled trial, UK United Kingdom, USA United States of America
  2. aWhere there are two sets of strategies it indicates the presence of multiple experimental groups within a study; where strategies are repeated it indicates the coding of the same strategy in two distinct components of the intervention
  3. bDirection of the recommendation is to increase behaviour, with the exception of one study as indicated with ‘–‘
  4. c‘+’represents positive and significant changes and a ‘Ø’ represents a null finding