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Table 2 Trial outcomes

From: Rationale and design of the Novel Uses of adaptive Designs to Guide provider Engagement in Electronic Health Records (NUDGE-EHR) pragmatic adaptive randomized trial: a trial protocol

Type Outcome Data source Definition When outcome is analyzed
Primary Reduction in inappropriate prescribing EHR Composite of (1) discontinuation of high-risk medications or (2) ordering a gradual dose taper End of stages 1 and 2
Secondary Quantity of prescribing EHR Number of milligram equivalents of high-risk medications prescribed to patients End of stage 2
Tertiary Quantity of medication dispensed Administrative claims Number of milligram equivalents of high-risk medications filled by patients End of stage 2
Adverse events Administrative claims Occurrence of clinically significant adverse drug events, such as all-cause hospitalizations, falls, and fractures End of stage 2
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