Cost-effectiveness of the Adaptive Implementation of Effective Programs Trial (ADEPT): approaches to adopting implementation strategies

Table 1 Model inputs

Parameter	Base	Low	High	Distribution^a	Source
Costs
Cost of REP (Phase I)^b	588.95	0	558.95	Normal	Time and resource tracking, study staff
Additional cost of EF (Phase II)	32.70	32.39	33.01	Normal	Time logs
Additional cost of EF (Phase III)	17.55	1.22	30.84	Normal	Time logs
Additional cost of EF and IF (Phase II)	31.23	28.51	30.49	Normal	Time logs
Additional cost of EF and IF (Phase III)	6.35	3.15	9.27	Normal	Time logs
Probabilities
Probability of response after Phase II with REP+EF	0.095	0	0.095		Site response data
Probability of response after Phase II with REP+EF/IF	0.091	0	0.091		Site response data
Utilities^c,d
REP only	.475	0.43	0.521	Beta	Patient survey
EF (Phase II)	.497	0.42	0.573	Beta	Patient survey
EF non-responding site (Phase III)	.446	0.306	0.586	Beta	Patient survey
EF responding site (Phase III)	.721	0.533	0.909	Beta	Patient survey
EF and IF (Phase II)	.463	0.362	0.564	Beta	Patient survey
EF add IF (Phase III)	.568	0.392	0.566	Beta	Patient survey
EF and IF non-responding site (Phase III)	.479	0.392	0.566	Beta	Patient survey
EF and IF responding site (Phase III)	.372	0.184	0.559	Beta	Patient survey

^aDistributions are parameterized such that the mean is the base value and the standard deviation is ¼ of the difference between the low and high values
^bPhases refer to values calculated within phases of the original trial: Phase I: baseline/initial 6-month period prior to the trial phase of the study with REP only, Phase II: second 6 months of the study, Phase III: final 6 months of the trial
^cInverse probability weighting to account for missing data with weights estimated from a logistic regression model for predicting non-response
^dEQ-5D calculated using mapping algorithm from components of the SF-12

ISSN: 1748-5908