RE-AIM Domain | Outcome |
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Reach | • Proportion of eligible PLHIV offered 3HP who accept to initiate treatment |
Effectiveness/cost-effectiveness | Effectiveness of intervention • Proportion of participants who initiate 3HP for whom treatment is discontinued due to adverse events or intolerance • Cumulative 16-month incidence of active TB Cost-effectiveness • Incremental cost of each delivery strategy per disability adjusted life year (DALY) averted • Incremental health system cost per DALY averted • Incremental patient cost per DALY averted |
Adoption | • Thematic results from healthcare provider key informant interviews |
Implementation | Fidelity of intervention and delivery strategy implementation • Proportion who complete at least 11 of 12 3HP doses within 16 weeks of starting treatment • Proportion reimbursed overall and on the same day as each 3HP clinic visit • Time spent at each clinic visit • Time spent on shared decision-making tool • Proportion of IVR phone call reminders delivered to participants for clinic visits or medication dosing • Proportion of IVR phone call reminders delivered to participants for missed appointments • Proportion of participants screened for active TB during DOT or refill visits • Proportion of participants screened for side effects during DOT or refill visits. • Proportion of doses confirmed using digital adherence technology. Doses directly observed (i.e., during initial or refill visits) will not be included in the denominatora • Proportion of IVR phone call reminders delivered to participants following missed dosesa • Proportion of weekly IVR phone call check-ins delivered to participantsa • Proportion of responses to weekly IVR phone call check-ins received from participantsa • Proportion of participants who receive appropriate follow-up (phone call or home visit) for lack of response/negative response to weekly check-in IVR phone calla Patient costs • Total direct and indirect patient costs related to TB preventive care services Acceptability of delivery strategy • Median scores for domains within the patient satisfaction survey • Median scores for domains within the SDM-Q-9 validated questionnaire on implementation of the shared decision-making tool Modification of targeted barriers • Self-reported patient barriers to TB preventative care services • Patient satisfaction with TB preventive care services • Provider- and clinic-level barriers to delivery of 3HP • Thematic results from patient in-depth interviews |