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Table 3 Comparison with other studies which evaluate the out-of-hospital impact of changes in a hospital drug formulary

From: Impact of a change of bronchodilator medications in a hospital drug formulary on intra- and out-of-hospital drug prescriptions: interrupted time series design with comparison group

Author/yearCountrySettingTherapeutic groupMethodologyPre-/post-intervention periodOther contextual factorsEffect
Vázquez-Mourelle et al./2017 [16]SpainPublic district hospitalPPIsInterrupted time series analysis1 January 2013/31 December 2015 (36 months)
Inclusion of omeprazole
NoneImmediate reduction in pantoprazole in hospital outpatient clinics and long-term reduction in primary care. Sharp and long-term rise in the percentage of omeprazole over total PPIs in hospital out-patient units and primary care respectively.
Vázquez-Mourelle et al./2019 [17]SpainPublic tertiary university teaching hospitalLMWHInterrupted time series analysis with control group1 January 2011/31 December 2016 (72 months)
Withdrawal of bemiparin and dalteparin
Restriction on use of tinzaparin
Maintenance of enoxaparin
NoneImmediate significant reduction of 55.6% in the medication that was withdrawn and a 9.0% reduction in the medication that was restricted. Immediate 32.6% increase in the drug retained as freely prescribable.
Gallini et al./2013 [14]FranceNational health systemSerotonin antagonists
ACE inhibitors
Ecological study of spatial clusters, analysed by multivariate linear regression with instrumental variables.NA (cross sectional)NonePositive influence of hospital-prescribed medications on community prescriptions. This influence varied, both with drug class, proving stronger in the classes used for the cardiovascular system, and with hospital size.
Larsen et al./2014 [15]DenmarkPublic tertiary university teaching hospitalPPIs (policy of replacing an expensive PPI (esomeprazole) with less expensive PPIs)Pre-post, descriptive statistics in exact numbers and percentages1 January 2009/31 December 2010 (policy change: switch to using a less expensive PPI)Esomeprazole was offered to hospital with a 90% discount, which was an expensive PPI out-of-hospital.The probability of having an expensive PPI after hospitalisation decreased from 13.4 to 6.5%, while use of recommended PPIs increased.
  1. LMWH low molecular weight heparins, EPO erythropoietin, PPIs proton pump inhibitors, ACE inhibitors angiotensin-converting enzyme antagonists inhibitors, ARBs angiotensin-receptor blockers, AAAs alpha-adrenoreceptor antagonists, SSRIs selective serotonin re-uptake inhibitors