Table 3 Comparison with other studies which evaluate the out-of-hospital impact of changes in a hospital drug formulary
Author/year | Country | Setting | Therapeutic group | Methodology | Pre-/post-intervention period | Other contextual factors | Effect |
|---|---|---|---|---|---|---|---|
Vázquez-Mourelle et al./2017 [16] | Spain | Public district hospital | PPIs | Interrupted time series analysis | 1 January 2013/31 December 2015 (36 months) Inclusion of omeprazole | None | Immediate reduction in pantoprazole in hospital outpatient clinics and long-term reduction in primary care. Sharp and long-term rise in the percentage of omeprazole over total PPIs in hospital out-patient units and primary care respectively. |
Vázquez-Mourelle et al./2019 [17] | Spain | Public tertiary university teaching hospital | LMWH | Interrupted time series analysis with control group | 1 January 2011/31 December 2016 (72 months) Withdrawal of bemiparin and dalteparin Restriction on use of tinzaparin Maintenance of enoxaparin | None | Immediate significant reduction of 55.6% in the medication that was withdrawn and a 9.0% reduction in the medication that was restricted. Immediate 32.6% increase in the drug retained as freely prescribable. |
Gallini et al./2013 [14] | France | National health system | Serotonin antagonists LMWH EPO PPIs ACE inhibitors ARBs Statins AAAs SSRIs | Ecological study of spatial clusters, analysed by multivariate linear regression with instrumental variables. | NA (cross sectional) | None | Positive influence of hospital-prescribed medications on community prescriptions. This influence varied, both with drug class, proving stronger in the classes used for the cardiovascular system, and with hospital size. |
Larsen et al./2014 [15] | Denmark | Public tertiary university teaching hospital | PPIs (policy of replacing an expensive PPI (esomeprazole) with less expensive PPIs) | Pre-post, descriptive statistics in exact numbers and percentages | 1 January 2009/31 December 2010 (policy change: switch to using a less expensive PPI) | Esomeprazole was offered to hospital with a 90% discount, which was an expensive PPI out-of-hospital. | The probability of having an expensive PPI after hospitalisation decreased from 13.4 to 6.5%, while use of recommended PPIs increased. |