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Table 5 Incremental cost-effectiveness for clinical practice and patient outcomes

From: Economic evaluation of the NET intervention versus guideline dissemination for management of mild head injury in hospital emergency departments

Variable ΔC ΔE ΔC / ΔE Parametric (95%CI) Non-parametric (95%CI)
Clinical practice outcomes (NET sample)
 PTA1 $169.89 (43, 297) 0.1363 (0.083, 0.190) $1246 ($525, $2055) ($595, $2066)
 INFO2 $169.89 (43, 297) 0.0315 (− 0.030, 0.093) $5393 ($1672,− $18,125) ($1909, − $22,865)
 SAFED3 $169.89 (43, 297) 0.0349 (0.010, 0.060) $4868 ($1882, $11928) ($2093, $11574)
Clinical outcomes and quality of life (NET-Plus sample)
 HADS Anxiety4 $505.06 (96, 915) − 0.52 (− 1.34, 0.30) $971^ ($132, − $1086) ($215, − $1084)
 Rivermead PCS5 $505.06 (96, 915) − 1.15 (− 2.77, 0.48) $441^ ($54, − $1270) ($90, − $1346)
 SF6D HRQoL6 $505.06 (96, 915) 0.030 (− 0.00, 0.06) $16,948 ($2015,-$367,759) ($3796,-$314,637)
  1. Parametric CIs derived via Fieller’s Theorem using iprogs.do [25] based on treatment effects reported in Tables 3 and 4 and using standard errors and correlations calculated from non-parametric bootstrap re-estimation
  2. Non-parametric CIs derived via acceptability method using bsceaprogs.do [25] based on the data generated from bootstrap re-estimation of our estimates of incremental cost and incremental effectiveness using bmultiv.do [25]
  3. 1Cost per patient appropriately screened for PTA (primary outcome)
  4. 2Cost per patient who received written patient information upon discharge (INFO)
  5. 3Cost per safe discharge (SAFED) where SAFED defined as CT scan appropriately provided plus PTA plus INFO
  6. 4Cost per point improvement on anxiety questions of Hospital Anxiety and Depression Scale (HADS), higher scores indicate higher levels of anxiety
  7. 5Cost per point improvement on the Rivermead post-concussive symptoms scale, higher scores indicate greater severity
  8. 6Cost per point improvement in SF6D index scores, higher scores indicate higher HRQoL
  9. ^Calculated as ΔC/− ΔE to reflect the fact that higher scores indicate greater severity for HADS and Rivermead