Table 5 Patient-level factor change coefficients and 95% confidence intervals for effects of implementation strategy and culture and climate measures, by the outcome, for 6-month intervals and 12 months cumulative post-randomization (N = 9225)

 Immediate vs. Delayed Enhanced REP at 6 months (vs. baseline)

8.24 (5.74, 11.83)*

9.69 (6.58, 14.27)*

10.10 (6.83, 14.95)*

 Immediate vs. Delayed Enhanced REP at 12 months (vs. baseline)

5.91 (3.99, 8.76)*

7.05 (4.63, 10.73)*

7.72 (5.04, 11.84)*

 Immediate Enhanced REP x culture/climate score at 6 months (vs. baseline)

2.81 (1.98, 3.98)*

3.05 (2.05, 4.55)*

2.56 (1.72, 3.81)*

 Immediate Enhanced REP x culture/climate score at 12 months (vs. baseline)

2.05 (1.41, 2.97)*

2.00 (1.30, 3.08)*

1.94 (1.27, 2.98)*

 BIC statistic

7241.7

7271.8

7727.7

 Immediate vs. Delayed Enhanced REP at 6 months (vs. baseline)

3.38 (2.42, 4.74)*

3.73 (2.64, 5.27)*

3.72 (2.64, 5.25)*

 Immediate vs. Delayed Enhanced REP at 12 months (vs. baseline)

2.35 (1.67, 3.31)*

2.52 (1.76, 3.59)*

2.58 (1.81, 3.68)*

 Immediate Enhanced REP x culture/climate score at 6 months (vs. baseline)

1.59 (1.12, 2.25)*

1.65 (1.14, 2.38)*

1.27 (0.88, 1.84)

 Immediate Enhanced REP x culture/climate score at 12 months (vs. baseline)

0.99 (0.69, 1.41)

0.98 (0.67, 1.43)

0.79 (0.55, 1.16)

 BIC statistic

7511.1

7531.0

7536.5

 Immediate vs. Delayed Enhanced REP at 6 months (vs. baseline)

1.59 (0.96, 2.63)

1.64 (0.97, 2.79)

1.66 (0.98, 2.78)

 Immediate vs. Delayed Enhanced REP at 12 months (vs. baseline)

1.22 (0.76, 1.98)

1.15 (0.69, 1.90)

1.18 (0.72, 1.94)

 Immediate Enhanced REP x culture/climate score at 6 months (vs. baseline)

1.07 (0.65, 1.77)

1.29 (0.74, 2.23)

1.01 (0.59, 1.75)

 Immediate Enhanced REP x culture/climate score at 12 months (vs. baseline)

0.92 (0.58, 1.48)

1.11 (0.66, 1.88)

0.96 (0.57, 1.63)

 BIC statistic

4873.4

4877.9

4880.8