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Table 5 Intervention influence on prescribed antibiotic class

From: Reduction of antibiotic prescriptions for acute respiratory tract infections in primary care: a systematic review

Antibiotic prescription rates
  Study arma Narrow-spectrum penicillins Broad-spectrum penicillins Cephalosporines Macrolides Quinolones Tetracyclines Other classes of antibiotics
Bjerrum et al. 2006
Spain
Included diagnoses: upper/lower RTI (e.g. acute otitis media, tonsillitis, pharyngitis, laryngitis, sinusitis, COPD, pneumonia)
IG T0 0.6% (95% CI 0.0–2.3%) 60.7% (95% CI 55.1–66.1%) 4.4% (95% CI 2.4–7.3%) 17.9% (95% CI 13.9–22.6%) 6.3% (95% CI 3.9–9.5%) 0.3% (95% CI 0.0–1.7%) 9.8% (95% CI 6.7–13.6%)
IG T1 7.9% (95% CI 5.3–11.2%) 65.3% (95% CI 60.0–70.3%) 0.9% (95% CI 0.2–2.5%) 7.0% (95% CI 4.5–10.2%) 7.0% (95% CI 4.5–10.2%) 0.0% (95% CI 0.0–1.1%) 11.9% (95% CI 8.7–15.9%)
CG T1 1.0% (95% CI 0.4–2.0%) 70.2% (95% CI 66.7–73.6%) 4.7% (95% CI 3.2–6.5%) 10.2% (95% CI 8.9–12.6%) 6.5% (95% CI 4.9–8.6%) 0.1% (95% CI 0.0–0.8%) 7.3% (95% CI 5.5–9.5%)
Gjelstad et al. 2013
Norway
Included diagnoses: acute upper/lower RTI (e.g. bronchitis, tonsillitis, pneumonia, sinusitis)
IG T0 43.8% 8.75% n.s. 26.6% n.s. 19.3% 1.23%
IG T1 53.2% (p < 0.001) 8.71% (p = 0.948) n.s. 22.9% (p = 0.003) n.s. 13.6% (p < 0.001) 1.20% (p = 0.876)
CG T0 43.5% 10.0% n.s. 25.5% n.s. 19.3% 1.43%
CG T1 41.7% (p = 0.045) 9.78% (p = 0.682) n.s. 27.8% (p = 0.006) n.s. 19.2% (p = 0.821) 1.46% (p = 0.908)
McGinn et al. 2013
USA
Included diagnoses: pharyngitis, pneumonia
  Penicillins Cephalosporines Macrolides Quinolones Tetracyclines Other classes of antibiotics
IG T1 24.0% 1.2% 65.5% 9.9% n.s. n.s.
CG T1 22.2% (p = 0.75) 1.3% (p = 0.82) 58.8% (p = 0.29) 19.6% (p = 0.02) n.s. n.s.
  1. RTI respiratory tract infection, n.s. not specified
  2. aIG intervention group, CG control group