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Table 2 Impact of academic detailing visits on primary outcomes in an intention to treat analysis

From: The implementation of academic detailing and its effectiveness on appropriate prescribing of pain relief medication: a real-world cluster randomized trial in Belgian general practices

  Step change (β6) [99% Wald CI] Change in trend (β7) [99% Wald CI]
Odds of being reimbursed for an analgesic or NSAID, in intervention compared to control group (PO1) 0.9980 [0.9834; 1.0128] 0.9889 [0.9767; 1.0013]
Average defined daily dose of paracetamol per patient reimbursed for paracetamol per month, in intervention compared to control group (PO2) − 0.3287 [− 1.0491; 0.3917] 0.0386 [− 0.1973; 0.2745]
Odds of being reimbursed for a recommended NSAID when reimbursed for any NSAID, in intervention compared to control group (PO3) 1.1903*[1.0757; 1.3171] 0.9901 [0.9719; 1.0086]
Odds of being reimbursed for an NSAID and a PPI when reimbursed for an NSAID, in intervention compared to control group (PO4) 1.0217 [0.9243; 1.1294] 0.9926 [0.9685; 1.0173]
  1. Step change difference in step change between the intervention and control group immediately after the intervention; change in trend difference between the change in trend between the intervention and control group after the intervention; CI confidence interval, NSAID nonsteroidal anti-inflammatory drug, PPI proton pump inhibitor; *p value < 0.01; underlined < 0.01 in all four analyses (ITT, ITT-V1, ITT-V2 and PPR)