Table 4 Selected infant characteristics and outcomes according to exposure to MgSO4 for fetal NP and its indication (N (%) or median [IQR], where appropriate, unless otherwise indicated)
MgSO4 for neuroprotection N = 5314 | No MgSO4 N = 7238 | MgSO4 for another indication N = 1556 | p value | |
|---|---|---|---|---|
Antenatal and birth characteristics | ||||
GA, weeks and days | 29 [26, 30] | 29 [27, 30] | 29 [27, 30] | < 0.001 |
24 weeks (and 0 days)–28 weeks (and 6 days) | 2634 (49.6%) | 3198 (44.2%) | 682 (43.8%) | < 0.001 |
29 weeks (and 0 days)–31 weeks (and 6 days) | 2680 (50.4%) | 4040 (55.8%) | 874 (56.2%) | |
Male | 2908/5304 (54.8%) | 3974/7233 (54.9%) | 766 (49.9%) | < 0.001 |
Missing | 10 | 5 | 3 | |
Singleton | 3644 (68.6%) | 5095 (70.4%) | 1189 (76.5%) | < 0.001 |
Missing | 0 | 1 | 1 | |
Small gestational age | 545 (10.3%) | 541 (7.5%) | 277 (17.8%) | < 0.001 |
Missing | 8 | 5 | 3 | |
Maternal chorioamnionitis | 995 (23.5%) | 1046 (21.0%) | 168 (15.0%) | < 0.001 |
Missing | 1085 | 2264 | 439 | |
Antenatal corticosteroids | 5127 (96.9%) | 5827 (81.7%) | 1477 (95.8%) | < 0.001 |
Missing | 23 | 108 | 14 | |
Outborn | 299 (5.6%) | 1484 (20.5%) | 128 (8.2%) | < 0.001 |
Missing | 0 | 6 | 2 | |
Delivered by caesarean | 3082 (58.1%) | 4260 (59.0%) | 1119 (72.2%) | < 0.001 |
Missing | 7 | 13 | 5 | |
Intensive resuscitation | 1630 (30.9%) | 2828 (39.6%) | 466 (30.3%) | < 0.001 |
Missing | 33 | 91 | 19 | |
Adjusted OR (vs no use)* | 0.63 [0.54, 0.73] | Reference | – | < 0.001 |
Adjusted OR (vs other use)* | 0.81 [0.66, 0.99] | – | Reference | 0.04 |