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Table 4 Selected infant characteristics and outcomes according to exposure to MgSO4 for fetal NP and its indication (N (%) or median [IQR], where appropriate, unless otherwise indicated)

From: MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP)—implementation of a national guideline in Canada

  MgSO4 for neuroprotection N = 5314 No MgSO4 N = 7238 MgSO4 for another indication N = 1556 p value
Antenatal and birth characteristics
 GA, weeks and days 29 [26, 30] 29 [27, 30] 29 [27, 30] < 0.001
 24 weeks (and 0 days)–28 weeks (and 6 days) 2634 (49.6%) 3198 (44.2%) 682 (43.8%) < 0.001
 29 weeks (and 0 days)–31 weeks (and 6 days) 2680 (50.4%) 4040 (55.8%) 874 (56.2%)
 Male 2908/5304 (54.8%) 3974/7233 (54.9%) 766 (49.9%) < 0.001
  Missing 10 5 3  
 Singleton 3644 (68.6%) 5095 (70.4%) 1189 (76.5%) < 0.001
  Missing 0 1 1  
 Small gestational age 545 (10.3%) 541 (7.5%) 277 (17.8%) < 0.001
  Missing 8 5 3  
 Maternal chorioamnionitis 995 (23.5%) 1046 (21.0%) 168 (15.0%) < 0.001
  Missing 1085 2264 439  
 Antenatal corticosteroids 5127 (96.9%) 5827 (81.7%) 1477 (95.8%) < 0.001
  Missing 23 108 14  
 Outborn 299 (5.6%) 1484 (20.5%) 128 (8.2%) < 0.001
  Missing 0 6 2  
 Delivered by caesarean 3082 (58.1%) 4260 (59.0%) 1119 (72.2%) < 0.001
  Missing 7 13 5  
Intensive resuscitation 1630 (30.9%) 2828 (39.6%) 466 (30.3%) < 0.001
  Missing 33 91 19  
Adjusted OR (vs no use)* 0.63 [0.54, 0.73] Reference < 0.001
Adjusted OR (vs other use)* 0.81 [0.66, 0.99] Reference 0.04
  1. *Adjusted for gestational age, gender, small for gestational age, singleton, outborn status, delivery by caesarean and administration of corticosteroids. Chorioamnionitis was not included due to a large proportion of missing variables