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Table 1 Characteristics of included studies (n = 14)

From: Effective strategies for scaling up evidence-based practices in primary care: a systematic review

Reference in chronological order

General characteristics

Targeted units

Component of scaling-up strategya

Outcomes

Outcomes

Country economic status

Funding source

Clinical area

Study design

Setting

Evidence-based practice

 

C1

C2

C3

C4

C5

Scaling-up processb

Health system

Provider

Patient

Frieden et al. [51]

MIC

Governmental organization

Tuberculosis

Non-RCT

State and district health tuberculosis units

Treatment, short-course (DOTS) strategy for tuberculosis control

Region, patient

   

⊠

 

Coverage

  

Sputum smear conversion, cure rate; treatment success

Price et al. [52]

LIC

Governmental organization

HIV

Before-after

Primary health centers

Basic HIV care

Site

 

⊠

      

Reproductive health, services for children, curative services

Mutevedzi et al. [53]

MIC

Governmental organization

HIV

Before-after

Primary health care clinics

HIV treatment and care program

Site, patient

   

⊠

    

Retention in care, mortality, loss to follow-up and virological outcomes

Renju et al. [54]

LIC

Governmental organization

Sexually transmitted infection and reproductive health

Before-after

Health units (hospitals, health centers and dispensaries)

Youth-friendly services (YES) intervention

Site, provider

   

⊠

   

Knowledge and attitudes of health workers

 

Curry et al. [55]

LIC

Voluntary/charitable body

Child care

Before-after

Primary health care units

Some items of Millennium Rural Initiative (EMRI)

Site

⊠

  

⊠

 

Cost-benefit ratio of the EMRI program

Health centre infrastructure and performance

 

Maternal and child survival

Goetz et al. [56]

HIC

Research funding body

HIV

Non-RCT

Veterans' healthcare administration facilities

A multimodal program to promote HIV testing

Site

 

⊠

 

⊠

  

Semi-annual patient load per facility, number of patient visits per year, prevalence of HIV, complexity level

Number of providers seeing the patients during the 6 months of routine testing

HIV testing

Li et al. [57]

HIC

Governmental organization

Preventing seniors' falls

Before-after

Local senior and community centers

Tai Ji Quan: Moving for Better Balance

Provider

   

⊠

 

Coverage; measures of program implementation, maintenance and effectiveness

  

Body mass index, incidence of falls, fear of falling, health status, number of chronic medical conditions

Miyano et al. [58]

MIC

Not found

Tuberculosis

CBA

Hospitals and rural health centers

Antiretroviral therapy (ART) services program

Site

⊠

  

⊠

    

HIV testing, tuberculosis treatment outcomes (success, died/failed)

Comfort et al. [59]

MIC

Governmental organization

Malaria

Before-after

Hospitals: rural health centers and primary health centers

Malaria control interventions

Site, patient

 

⊠

 

⊠

  

Costs incurred for malaria admissions

 

Hospital admissions, outpatient visits for malaria

Legesse et al. [60]

LIC

Governmental organization

Child care

Non-RCT

Primary health care units

Integrated community case management (iCCM) program

Region, site, patient

⊠

⊠

 

⊠

 

Key indicators of iCCM implementation strength, quality of care, utilization of iCCM services, service

  

Syndromes treated (malaria, suspected pneumonia, diarrhea, severe acute malnutrition)

Solberg et al. [61]

HIC

Not found

Depression

RCT

Primary care clinics

The IMPACT (Improving Mood: Promoting Access to Collaborative Treatment) model

Site, patient

⊠

 

⊠

⊠

    

Depression remission rates, satisfaction with care, work productivity, health status

Sim et al. [62]

MIC

Voluntary/charitable body

HIV

Before-after

Public health facilities

Linked Response (LR) model

Region, site

     

Coverage

  

Pregnant women's access to HIV testing and treatment

Munos et al. [63]

LIC

Governmental organization

Child care

Non-RCT

Health districts

iCCM for diarrhea, malaria and pneumonia

Region

⊠

⊠

⊠

⊠

    

Program targets of mortality and coverage, intensity and quality of program implementation, careseeking.

Singh et al. [64]

MIC

Voluntary/charitable body

Child care

Before-after

Health facilities (health posts, health centers, and hospitals)

Project Fives Alive!

Site

⊠

  

⊠

    

Early antenatal care, skilled delivery coverage, underweight infants at child welfare clinics, under-fives

  1. MIC middle-income country, LIC low-income country, HIC high-income country, RCT randomized controlled trial, CBA controlled before-and-after, HIV human immunodeficiency virus, DOTS directly observed treatment, short-course, YES youth friendly services, EMRI Ethiopian Millennium Rural Initiative, ART antiretroviral therapy, iCCM integrated community case management, IMPACT Improving Mood: Promoting Access to Collaborative Treatment, LR linked response
  2. aComponents of scaling-up strategy: (C1) healthcare infrastructure, (C2) policy/regulation, (C3) financing, (C4) human resources, and (C5) patient involvement
  3. bSee Table 2 for more details regarding scaling-up coverage of the targeted units
  4. ⊠ means that the scaling-up strategy component was used in the study