Table 1 Secondary prescribing outcomes from interim analysis

Per protocol

n = 2820

n = 2914

n = 2947

n = 3934

n = 4093

n = 4162

 Antipsychotic daily dose in the past 28 days (mean ± SD)^a

120 ± 155

116 ± 136

122 ± 152

127 ± 156

133 ± 160

125 ± 156

 Antipsychotic [n(%)]

639 (22.7%)

630 (21.6%)

624 (21.2%)

890 (22.6%)

903 (22.1%)

898 (21.6%)

 Acetaminophen [n(%)]

1237 (43.9%)

1263 (43.3%)

1244 (42.2%)

1677 (42.6%)

1749 (42.7%)

1736 (41.7%)

 Antidepressant [n(%)]

1436 (50.9%)

1478 (50.7%)

1495 (50.7%)

2000 (50.8%)

2085 (50.9%)

2102 (50.5%)

 Benzodiazepine [n(%)]

261 (9.3%)

275 (9.4%)

273 (9.3%)

427 (10.9%)

469 (11.5%)

414 (9.9%)

As-treated

n = 2342

n = 2421

n = 2453

n = 4412

n = 4586

n = 4656

 Antipsychotic daily dose in the past 28 days (mean ± SD)^a

118 ± 151

114 ± 132

117 ± 145

128 ± 158

132 ± 160

128 ± 159

 Antipsychotic [n(%)]

556 (23.7%)

548 (22.6%)

535 (21.8%)

973 (22.1%)

985 (21.5%)

987 (21.2%)

 Acetaminophen [n(%)]

992 (42.4%)

1,006 (41.6%)

988 (40.3%)

1,922 (43.6%)

2,006 (43.7%)

1,992 (42.8%)

 Antidepressant [n(%)]

1160 (49.5%)

1200 (49.6%)

1210 (49.3%)

2276 (51.6%)

2363 (51.5%)

2387 (51.3%)

 Benzodiazepine [n(%)]

232 (9.9%)

243 (10.0%)

238 (9.7%)

456 (10.3%)

501 (10.9%)

449 (9.6%)