Table 1 Evolution of the EtD framework

Used on the World Health Organization and Spanish Guidelines program

Used in Kingdom of Saudi Arabia, World Allergy Organization, Colombian guideline program and rare diseases guidelines

Did not include “prioritization of the problem”

Included a question evaluating the priority of the problem

Included a single question evaluating the balance between health benefits and harms of the intervention of interest

The original question was disaggregated into 3 questions: (1) the magnitude of the health benefits, (2) the magnitude of the health harms, and (3) the balance between health benefits and harms.

Included a single question evaluating the variability of patients’ values and preferences

A judgment regarding the uncertainty about patients’ values and preferences was added.

Included a single question evaluating the cost of the intervention in relation to the benefits

The original question was disaggregated into 2 questions: (1) what is the cost of the intervention and (2) how large is this cost in relation to the benefits.

Included equity as an additional criterion

Acceptability and feasibility were added to equity