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Table 2 Results from multivariable mixed-effect regression analyses of the effect of the IDOCC intervention

From: A real-world stepped wedge cluster randomized trial of practice facilitation to improve cardiovascular care

Parameter Model A Model B Model C
(Unadjusted) (Adjusted for patient factors) (Adjusted for patient/provider factors)
Estimatea P value 95 % CI Estimatea P value 95 % CI Estimatea P value 95 % CI
Intercept 61.4 <0.0001 56.7 to 66.1 39.2 <0.0001 32.6 to 45.9 44.97 <0.0001 34.8 to 55.1
Time          
 Year 1 Ref - - Ref - - Ref - -
 Year 2 1.5 <0.0001 0.8 to 2.3 0.9 0.02 0.2 to 1.7 0.9 0.019 0.2 to 1.7
 Year 3 4.2 <0.0001 3.2 to 5.3 3.0 <0.0001 1.9 to 4.0 3.0 <0.0001 1.9 to 4.0
 Year 4 6.3 <0.0001 4.6 to 7.9 4.4 <0.0001 2.8 to 6.0 4.4 <0.0001 2.8 to 6.0
 Year 5 7.3 <0.0001 5.1 to 9.5 4.9 <0.0001 0.027 to 0.071 4.9 <0.0001 2.7 to 7.1
Intervention phase          
 Baseline Ref - - Ref - - Ref - -
 Intensive −2.1 <0.0001 −3.2 to −1.1 −1.9 0.0003 −2.9 to −0.9 −1.9 0.0003 −2.9 to −0.9
 Sustainability −4.7 <0.0001 −6.2 to −3.2 −4.2 <0.0001 −5.7 to −2.6 −4.2 <0.0001 −5.7 to −2.6
Region          
 Region 1 Ref - - Ref - - 1.0 0.789 −6.6 to 8.7
 Region 2 1.1 0.756 −5.9 to 8.1 1.4 0.695 −5.5 to 8.3 4.1 0.25 −2.9 to 11.0
 Region 3 3.8 0.205 −2.1 to 9.7 3.5 0.24 −2.3 to 9.3 2.7 0.531 −5.7 to 11.0
 Region 4 2.4 0.535 −5.3 to 10.2 2.3 0.545 −5.3 to 9.9 0.2 0.956 −6.7 to 7.1
 Region 5 2.4 0.441 −3.6 to 8.3 0.8 0.780 −5.1 to 6.8 3.7 0.293 −3.2 to 10.6
 Region 6 4.5 0.157 −1.7 to 10.7 3.7 0.231 −2.4 to 9.9 5.4 0.184 −2.6 13.4
 Region 7 5.7 0.121 −1.5 to 13.0 5.7 0.116 −1.4 to 12.9 Ref - -
 Region 8 −1.3 0.745 −9.0 to 6.4 −1.0 0.798 −8.6 to 6.6 4.8 0.189 −2.4 to 12.1
 Region 9 2.3 0.454 −3.7 to 8.3 2.2 0.476 −3.9 to 8.1 2.1 0.576 −5.1 to 9.2
Patient level  
 Age     0.03 0.168 −0.01 to 0.06 0.03 0.14 −0.009 to 0.07
 Sex     0.09 0.825 −0.7 to 0.9 0.07 0.872 −0.8 to 0.9
 Income     0.39 0.004 0.1 to 0.7 0.4 0.0035 0.13 to 0.67
 # of cardiovascxular-related diseasesb          
  0 (risk factors Only)     Ref - - Ref - -
  1     4.8 <0.0001 3.9 to 5.8 4.8 <0.0001 3.9 to 5.8
  2     6.9 <0.0001 5.7 to 8.0 6.9 <0.0001 5.7 to 8.0
  3     6.6 <0.0001 5.1 to 8.1 6.6 <0.0001 5.1 to 8.2
  4     7.4 <0.0001 4.9 to 9.9 7.4 <0.0001 4.9 to 9.9
  5     11.0 0.001 4.3 to 17.6 11.0 0.0012 4.4 to 17.6
 # of risk factors for cardiovascular diseasec          
  0     Ref - - Ref - -
  1     6.5 0.0009 2.6 to 10.3 6.5 0.0009 2.6 to 10.3
  2     12.7 <0.0001 9.0 to 16.4 12.7 <0.0001 8.9 to 16.4
  3     17.1 <0.0001 13.4 to 20.9 17.1 <0.0001 13.4 to 20.9
  4     4.7 0.017 0.8 to 8.5 4.6 0.019 0.8 to 8.5
 Rural     0.0099 0.103 −0.2 to 2.2 0. 9 0.141 −0. 3 to 2.1
Provider level          
 Payment model          
  FFS        Ref - -
  Capitation        1.4 0.437 −2.1 to 4.9
  Salary        9.0 0.710 −3.7 to 5.5
 Female physician        1.7 0.320 −1.6 to 5.0
 Years since graduation (as of 2010)        −0.27 0.0015 −0.4 to −0.1
  1. aNegative estimate indicates a decrease in adherence
  2. bCardiovascular-related diseases examined: stroke, coronary artery disease, peripheral vascular disease, diabetes, chronic kidney disease
  3. cRisk factors assessed were age, hypertension, dyslipidemia, and smoking