Table 1 Sample size estimates based on two-sided alpha = 0.05 for pairwise condition comparisons and 80 % power
Effect size | Total sample size for an ordinary RCT (3 arms) | ICC | Number of providers | Average number of patients per provider | Total sample size for a cluster RCT unadjusted for estimated MI uptake | Total sample size for a cluster RCT adjusted for estimated MI uptake |
|---|---|---|---|---|---|---|
d = 0.4 | 300 | 0.07 | 31 | 31 | 930 | 1116 |
40 vs 18 % | 195 | 0.1 | 30 | 17 | 510 | 765 |