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Table 1 Framework for situational analysis exploring phases of care, tasks, staff roles and time frames

From: Thrombolysis ImPlementation in Stroke (TIPS): evaluating the effectiveness of a strategy to increase the adoption of best evidence practice – protocol for a cluster randomised controlled trial in acute stroke care

Phase

Task

Staff

Time frame

1. Pre-hospital assessment

Assess potential tPA eligibility

Paramedic

<2 h of onset

Whether probable stroke or stroke mimic, define time of onset, consider comorbidity/frailty, estimate for survival

Deliver to tPA-capable hospital

Paramedic

Handover to triage or Acute Stroke Team

to ED/SCU

2. Triage

Assess tPA eligibility

ED or SCU

<3.5 h of onset

Onset time, collateral history, mRS, anticoagulants, seizure, serious or advanced terminal illness, history of intracranial haemorrhage or subarachnoid haemorrhage, major internal surgery in last 21 days, heart attack with IV thrombolysis in last 72 hours, stroke severity assessment with National Institutes of Health Stroke Scale, Glasgow Coma Scale, observations

Handover to SCU

to Acute Stroke Team

3. Clinical assessment

Assess tPA eligibility

SCU Nurse

Onset time certainty, functional independence, comorbidity, current medication, relative and absolute contraindications, NIHSS score, collect blood, notify CT scanning & organise transport, organise ECG

Handover to Imaging

to Radiography

4. Imaging

Non- contrast CT scan (or perfusion CT or MRI)

Radiography

Handover to SCU

to SCU Nurse

5. Final clinical assessment

Confirm tPA eligibility

SCU Medical

Review information from phase 1-3, focussed history to check for stroke mimic, onset certainty, premorbid functional independence, medication, contraindications, NIHSS, rapid cardiac and vascular screen, check blood sent to lab, review ECG, review NCCT on console with radiographer and again for degree of ischaemic change & possibility of stroke mimic, discuss scenarios with patient and family

6. Preparation & delivery

tPA Preparation

SCU Nurse

<4.5 h of onset

Check serum glucose level, anticoagulant medication, International Normalized Ratio, Blood Pressure, NIHSS.

Treat serum glucose or Blood Pressure if necessary and reassess

SCU Nurse

Administer thrombolysis, with amount based on estimated patient weight

SCU Nurse

7. Monitor

Monitor and manage neurological status (NIHSS at 0 h, 1 h, 24 hrs), blood pressure and serum glucose level

SCU/ICU

staff

24 h from tPA delivery