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Table 2 Clinical topics and number of panelists selecting each topic at each survey round (*: indicates the round at which the topic was selected)

From: Decision boxes for clinicians to support evidence-based practice and shared decision making: the user experience

a) Genomic topics   No of panelists
   Round 1 Round 2
· Screening for BRCA1 or BRCA2 gene mutations to evaluate the risk of breast and ovarian cancer   5 7*
· Newborn screening for sickle cell anemiaa   0 -
· Newborn screening for MCAD (medium chain acyl-CoA dehydrogenase) deficiency   0 -
· Hereditary colorectal cancer screening in individuals with high risks of colorectal and endometrial cancers   1 4*
· Screening for hereditary hemochromatosis in patients with abnormal ferritin level or abnormal transferrin saturation or in patients with family members with hemochromatosis   0 -
· Prenatal screening for the detection of Down’s syndrome, Trisomy 18, and open neural tube defects   5 7*
· Genotype testing for patients initiating warfarin treatment   1 3
· Screening for hypertrophic cardiomyopathy (HCM) in individuals with clinical features or a family history of HCM   0 -
· Testing for CDKN2A and CDK4 gene mutations to evaluate the risk of melanoma and the predisposition for pancreatic cancer   1 0
· Genetic testing for factor V Leiden to identify those at an increased risk for venous thromboembolism (VTE).   0 -
Additional topics proposed by the panelists at first round    
· Screening for hereditary prostate cancer   - -
· Screening for MEN predisposing mutations   - 0
b) Other topics No of panelists
  Round 1 Round 2 Round 3
· Colorectal cancer screening with faecal occult blood test 7* - -
· Prostate cancer screening with the prostate-specific antigen (PSA) test 7* - -
· Abdominal aortic aneurysm screening with abdominal ultrasound 1 - -
· Treatment of mild to moderate depression with selective serotonin reuptake inhibitors (SSRIs) or St. John’s wort 2 - -
· Treatment of Alzheimer’s disease with cholinesterase inhibitors 5 4 5*
· Antibiotic treatment for patients with exacerbated chronic obstructive pulmonary disease (COPD) 4 4 4
· Intensive glycemic control in type 2 diabetes 4 4 5*
· Prevention of strokes with antithrombotic therapy in patients with atrial fibrillation 3 - -
· Prevention of cardiovascular events with antihypertensive drug in patients over 60 years old presenting with essential hypertension 4 2 -
· Prevention of vascular diseases with acetylsalicylic acid (ASA) 6 6 7*
· Prevention of osteoporotic fractures with bisphosphonates (alendronate, risedronate, etidronate) in postmenopausal women 6 4 7*
· Primary prevention of cardiovascular disease with statins in persons with cardiovascular risk factors 5 4 7*
· Prevention of cervical cancer with the vaccine against the human papillomavirus (HPV) 3 - -
Additional topics proposed by the panelists at first round    
· Antibiotics versus nasal steroids for the treatment of acute sinusitis in adults - 1 -
· Early palliative care for patients with metastatic non–small-cell lung cancer - 1 -
· Omega-3 for mild to moderate depression - 1 -
· Delayed versus immediate antibiotic prescriptions for acute uncomplicated urinary tract infection in women - 0 -
· Prevention of prostate cancer with 5 alpha-reductase inhibitors (finasteride and dutasteride) - 2 -
· Breast cancer screening for women age 40 to 50 with no risk factors - 1 -
· Prevention of breast cancer with tamoxifen - 2 -