Reference | Adequate sequence generation | Concealment of allocation | Blinded or objective assessment of primary outcome(s) | Adequately addressed incomplete outcome data | Free from selective reporting | Free from other risk of bias | Similar baseline characteristics | Similar baseline outcome measures | Adequate protection against contamination |
---|---|---|---|---|---|---|---|---|---|
Gardner 2005 [46] | Yes | Unclear | Unclear | Yes | Unclear - protocol not published; trial registration number not reported. | Unclear - only approx. 20% of patients approached were included in the study. 40% of patients deemed eligible declined to enter study. | Unclear - not reported. | Yes for treatment; unclear for BMD scanning. | Unclear - patient randomised, PCPs not reported. |
Feldstein 2006 [47] | Yes | Yes | Yes | Yes | Unclear - protocol not published; trial registration number not reported. | Yes | Yes | Yes | Unclear - patient randomised: 15 primary care clinics involved with 159 PCPs, average one to three patients per PCP. |
Davis 2007 [48] | Yes | No | No | Yes | Unclear - protocol not published; trial registration number not reported. | Yes | Yes | Yes for treatment; unclear for BMD scanning. | Unclear - patient randomised, PCPs not reported. |
Majumdar 2007 [49] | Yes | Yes | Yes | Yes | Yes for primary outcome; no for secondary outcomes. | Yes | Yes | Yes for treatment; unclear for BMD scanning. | Unclear - possibility of contamination if control and intervention patients on ward at same time. |
Solomon 2007 [50] | Unclear | Unclear | Unclear | Yes | Unclear - protocol not published; trial registration number not reported. | Yes | Yes | Yes | Unclear - physician randomised but practices in which they worked not reported on. |
Cranney 2008 [51] | Yes | Yes | Yes | Yes | Unclear - protocol not published; trial registration number not reported. | Yes | Yes | Yes | Yes |
Majumdar 2008 [52] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes for treatment; unclear for BMD scanning. | Yes |
Miki 2008 [53] | Unclear | Unclear | No | Yes | Unclear - protocol not published; trial registration number not reported. | Unclear - stopped early as deemed unethical to continue following interim analysis. | Yes | Yes | Yes |
Rozental 2008 [54] | Unclear | Unclear | Unclear | Yes | Unclear - protocol not published; trial registration number not reported. | Yes | Yes | Yes for treatment; unclear for BMD scanning. | Unclear - patient randomised, PCPs not reported. |