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Table 2 Risk of bias of included studies

From: A systematic review of the effectiveness of interventions to improve post-fracture investigation and management of patients at risk of osteoporosis

Reference Adequate sequence generation Concealment of allocation Blinded or objective assessment of primary outcome(s) Adequately addressed incomplete outcome data Free from selective reporting Free from other risk of bias Similar baseline characteristics Similar baseline outcome measures Adequate protection against contamination
Gardner 2005 [46] Yes Unclear Unclear Yes Unclear - protocol not published; trial registration number not reported. Unclear - only approx. 20% of patients approached were included in the study. 40% of patients deemed eligible declined to enter study. Unclear - not reported. Yes for treatment; unclear for BMD scanning. Unclear - patient randomised, PCPs not reported.
Feldstein 2006 [47] Yes Yes Yes Yes Unclear - protocol not published; trial registration number not reported. Yes Yes Yes Unclear - patient randomised: 15 primary care clinics involved with 159 PCPs, average one to three patients per PCP.
Davis 2007 [48] Yes No No Yes Unclear - protocol not published; trial registration number not reported. Yes Yes Yes for treatment; unclear for BMD scanning. Unclear - patient randomised, PCPs not reported.
Majumdar 2007 [49] Yes Yes Yes Yes Yes for primary outcome; no for secondary outcomes. Yes Yes Yes for treatment; unclear for BMD scanning. Unclear - possibility of contamination if control and intervention patients on ward at same time.
Solomon 2007 [50] Unclear Unclear Unclear Yes Unclear - protocol not published; trial registration number not reported. Yes Yes Yes Unclear - physician randomised but practices in which they worked not reported on.
Cranney 2008 [51] Yes Yes Yes Yes Unclear - protocol not published; trial registration number not reported. Yes Yes Yes Yes
Majumdar 2008 [52] Yes Yes Yes Yes Yes Yes Yes Yes for treatment; unclear for BMD scanning. Yes
Miki 2008 [53] Unclear Unclear No Yes Unclear - protocol not published; trial registration number not reported. Unclear - stopped early as deemed unethical to continue following interim analysis. Yes Yes Yes
Rozental 2008 [54] Unclear Unclear Unclear Yes Unclear - protocol not published; trial registration number not reported. Yes Yes Yes for treatment; unclear for BMD scanning. Unclear - patient randomised, PCPs not reported.