Table 1 Candidate ICU clinical best practices considered for study

Prophylaxis against venous thromboembolism

Prevention of ventilator-associated pneumonia

Intensive insulin therapy to achieve tight glycemic control

Lung protective ventilation strategy

Daily interruption of sedation infusions

Restrictive transfusion strategy

Prophylaxis against gastric stress ulcers

Spontaneous breathing trials for mechanically-ventilated patients

Protocolized weaning from mechanical ventilation

Prevention of decubitus pressure ulcers

Provision of early enteral nutrition

Prevention of catheter-related blood stream infections

Pain assessment and management

Anxiety and delirium management

Improved end of life care